Molecular Targets

Charles River announces expansion of in vitro oncology services

30 October 2017 | By Charles River Laboratories

Partnership with InSphero provides additional 3D solutions...

Cell surface protein may offer target in treating childhood cancers

12 September 2017 | By Dr Zara Kassam (Drug Target Review)

Immunotherapy drug candidate could be potent weapon against neuroblastoma and other paediatric malignancies...

How receptors for medicines work inside cells

6 September 2017 | By Dr Zara Kassam (Drug Target Review)

G protein-coupled receptors are the key target of a large number of drugs, scientists have now been able to show more precisely how these receptors act in the cell interior...

PerkinElmer launches new IVIS® Lumina™ S5 and Lumina X5 systems for high throughput in vivo imaging

6 September 2017 | By PerkinElmer

Advanced 2D imaging and analysis help scientists rapidly trace anatomical and molecular aspects of diseases to advance drug discovery...

New technique speeds up chemical screening

23 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a high-throughput technique that can determine if a chemical has the potential to activate key genes in seconds...

Researchers identify powerful pain reliever

17 August 2017 | By Dr Zara Kassam (Drug Target Review)

A team of scientists  have discovered what they say is a powerful pain reliever that acts on a previously unknown pain pathway...

Tumours detected with sugar molecules

15 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have synthesised a complex sugar structure that specifically binds to the tumour protein Galectin-1...

Avenue discovered for precision cancer treatment

2 August 2017 | By Dr Zara Kassam (Drug Target Review)

A novel chemical dubbed "T-REX," along with a patent-pending targeting molecule have uncovered interesting facets of several well-known cancer-cell mutations that, if present in a patient, could inform treatment options and potentially produce more favourable outcomes...

Researchers use CRISPR-Cas9 to target retinal angiogenesis.

25 July 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to target retinal angiogenesis via an adeno-associated virus to deliver genomic edits to target vascular endothelial cell growth factor...

Intracellular target validation in cellular systems … using peptides!

7 July 2017 | By Paul Grant (Venomtech)

Paul Grant from Venomtech suggests that because animal venoms contain proteins and peptides that disrupt cell membrane integrity, they offer a new approach to drug discovery...

Study sheds light on how ovarian cancer spreads

28 June 2017 | By Niamh Marriott (Drug Target Review)

Long-term goal is to develop treatments that prevent cancer cells from attaching to new sites during metastasis.

Collaboration uses novel approach to identify antibacterial drug targets

27 June 2017 | By Drug Target Review

LifeArc, the UK medical research charity previously known as MRC Technology; The Centre for Drug Research and Development (CDRD); and the Defence Science and Technology Laboratory (Dstl), have announced a collaboration to identify antibacterial drug targets.

Snake venom might provide a safer antiplatelet drug

9 June 2017 | By Niamh Marriott (Drug Target Review)

In preliminary research, an antiplatelet drug based on a snake venom protein prevented blood clotting without leading to excessive bleeding, a dangerous side effect of currently available antiplatelet drugs. The venom protein may be the template for a new class of antiplatelet drugs that offers fewer bleeding complications.

The gut microbiota plays key role in diabetes treatment

2 June 2017 | By Niamh Marriott (Drug Target Review)

A clearer picture of how the classic diabetes medication metformin works has emerged.

GE Healthcare Ltd