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Prions

3D illustration showing neurons containing Lewy bodies small red spheres which are deposits of proteins accumulated in brain cells that cause their progressive degeneration

news

Fibril ‘fuzzy coats’ boost Parkinson’s protein spread

22 April 2025 | By Drug Target Review

New research reveals that the flexible ‘fuzzy coat’ surrounding α-synuclein fibrils plays a critical role in how Parkinson’s disease spreads between brain cells.

news

Analysis conducted on glycan structure from sheep prion strains

22 February 2021 | By Victoria Rees (Drug Target Review)

Using liquid chromatography/mass spectrometry, researchers have revealed no major differences in glycan structures in two prion strains.

news

Antisense oligonucleotides used to treat prion disease in animal models

11 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have shown that using antisense oligonucleotides to reduce the levels of prion protein in lab animals with prion disease can extended their survival.

news

Naturally occurring genetic variation gives complete resistance in prion diseases

11 June 2015 | By Victoria White

Researchers have identified a naturally occurring variant of the human prion protein that produces resistance to prion diseases such as CJD...

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Recommended

Prions

Fibril ‘fuzzy coats’ boost Parkinson’s protein spread

Analysis conducted on glycan structure from sheep prion strains

Antisense oligonucleotides used to treat prion disease in animal models

Naturally occurring genetic variation gives complete resistance in prion diseases