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MSK1’s importance for cognitive benefits
New study uncovers role of a neuronal protein kinase called mitogen- and stress-activated protein kinase 1 (MSK1) in mediating the cognitive benefits of environmental enrichment.
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Protein Expression
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Newly discovered mechanism behind cognitive decline in aging
US researchers say new mechanism could lead to new drugs and therapies to treat normal cognitive decline in aging.
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Alcohol-associated liver disease linked to abnormal splicing deregulation
Splicing deregulation is potential drug target and diagnostic tool, but can be affected by alcohol consumption and thus chronic liver disease.
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Are female mice better protected against obesity?
The University of California underwent a mouse study disclosing underlying sex differences in mice for obesity.
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Viruses can cause brain cells to fuse leading to a malfunctioning CNS
Researchers from Australia explore how viruses can alter brain cells, and thus the functions of our nervous system, leading to neurological symptoms.
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Ancient virus holds connections to ALS in people
US study identifies promising new target, in protein remnants from an ancient virus, for treating underlying cause of ALS.
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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering
In this article Dr Raymond Winquist, Oncology Fellow at Alkermes, covers the longstanding research challenges associated with cytokines: IL-12 and IL-18, and their untapped potential in immunotherapy and immuno-oncology.
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Targeted therapy for treatment-resistant breast cancer
US researchers have uncovered a potential target for treating breast cancer that is resistant to endocrine therapies because of a specific gene mutation.
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Potential pathway to improved stroke recovery
Japanese researchers identify a protein that reduces inflammation, stimulates neural growth, and improves sensory and motor functions following ischemic stroke in mice.
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Diverse senescent cell populations uncovered by single-cell RNA sequencing
Single-cell transcriptomic RNA sequencing analysis has allowed US researchers to identify the specific populations and the dynamic transition states during senescence initiation and progression.
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New treatment pathway for deadly pancreatic cancers
US scientists have used mouse models of pancreatic cancer to identify genes used by tumour cells to grow uncontrollably.
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Stem cell discovery has potential to impact cancer treatments
A team from Trinity College Dublin have uncovered mechanisms that stem cells use to establish cellular identity, a process that will have potential in cancer and targeted treatments.
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SARS-CoV-2 spike protein dihedral angle oscillations reveal favoured rotation frequencies
As new variants of the SARS-CoV-2 virus emerge, leading scientists Dr Oscar Bastidas and Dr Zoran Sevarac explore how their latest research identified a structured frequency domain profile in data with no discernible pattern. Their article also emphasises that it remains imperative to continue learning about this pathogen’s molecular machinery…
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Drug Target Review Vaccine development ebook 2023
In this ebook are articles on the future potential for mRNA therapies and combatting new variants of the SARS-CoV-2.
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New genes modulate toxicity of the protein that causes Alzheimer’s
Scientists from Spain have identified genes that regulate Alzheimer’s disease, including Surf4, which alters the regulation of calcium within Alzheimer’s cells.
