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17 January 2019 | By Drug Target Review
Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...
21 December 2018 | By Sphere Fluidics Ltd.
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
10 December 2018 | By Iqra Farooq (Drug Target Review)
Liquid-phase electron microscopy could overcome limitations identified through traditional protein imaging techniques and through cro-electron microscopy...
10 December 2018 | By Christopher J. Langmead
G protein-coupled receptors (GPCRs) are seven transmembrane spanning proteins that mediate the physiological responses to a broad array of stimuli, including photons, biogenic amines, peptides and large proteins. They represent the target of approximately one-third of all approved drugs,1 yet paradoxically remain a relatively under-exploited protein class.
10 December 2018 | By Anowarul Amin
In the wake of the human genome project, molecular biology and genetic technologies are tremendously integrating into biomedical research. Currently, PCR, qPCR, and sequencing are key tools in the clinical laboratory for the detection and characterisation of microorganisms and genetic disorders.
6 December 2018 | By Drug Target Review
Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...
5 December 2018 | By BMG Labtech GmbH
The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.
5 December 2018 | By Iqra Farooq (Drug Target Review)
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
Application note: A complete next-generation sequencing workflow for circulating cell-free DNA isolation and analysis
29 November 2018 | By Thermo Fisher Scientfic
Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.
16 November 2018 | By Drug Target Review
Scientists have uncovered a promising drug candidate that appears to normalise the vocal communication mechanism deficiencies experienced in genetic disorder ADNP.
14 November 2018 | By Drug Target Review
A team of neurologists have found that one reason Lewy bodies develop is that a molecule, USP13, has removed all the "tags" placed on alpha-synuclein that mark the protein for destruction...
12 November 2018 | By Iqra Farooq (Drug Target Review)
A swarm of billions of exosomes armed with proteins has been shown to assist in the fight against bacteria inhaled through the nose...
6 November 2018 | By Drug Target Review
Scientists in the United States have inadvertently uncovered a promising treatment for melanoma that targets the NGLY1 gene.
31 October 2018 | By Drug Target Review
A team of scientists led by Stanford University School of Medicine has identified a link between how proteins bind to our DNA and how cancer develops. This finding may allow researchers to predict cancer pathways and long-term patient outcomes.