Scientists have identified potential cancer drugs to treat pulmonary hypertension using experimental and computational approaches.
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The metagenomic method, termed SMAGLinker, could improve the accuracy and resolution of microbial characterisation to improve medicine design.
View Drug Target Review's new infographic on the use of AI and informatics within early therapeutic development here.
Organ-on-a-chip models can provide an alternative to cell cultures, animal models and traditional assays. In this article, Dr Désirée Goubert, Thomas Olivier, Luuk de Haan and Dr Lenie van den Broek explore the advantages of organ-on-a-chip technologies and how they can enable the in vitro study of three-dimensional (3D) cell migration in…
Sinopia has been awarded a $3.3 million Fast-Track SBIR grant to fund the study for its small molecule candidate for Parkinson’s disease.
Researchers have used CRISPR and cryogenic electron microscopy to unravel the workings of two receptors involved in diseases such as cancer and COVID-19.
The new CRISPR-based technology called MIC-Drop rapidly identified several genes for heart development and function in zebrafish.
Artificial intelligence was shown to predict the 3D shapes of RNA molecules, which could significantly advance RNA therapeutics.
An artificial intelligence technique can identify which neoantigens are recognised by the immune system, possibly improving cancer prognosis and treatment.
CRISPR holds great promise in advancing pharmacological research and has fuelled the rapid expansion of using gene-edited cells for drug discovery processes. CRISPR-Cas9 dropout screens have emerged as a useful tool for high-throughput large-scale loss-of-function screens, which seek to identify the relationship between genotype and phenotype. Dr Pushpanathan Muthuirulan, Research…
Sheraz Gul explores how machine learning and artificial intelligence represent an exciting opportunity for the drug discovery industry, with the potential to develop highly optimised small molecules.
Researchers have established an organoid biobank to search for genes that are essential for the spreading of SARS-CoV-2 infection.
New technology system of drug-based markers for the selection or counter-selection of genes may advance genetic screening methods.
New genomic study reveals that the microbiome could predict rheumatoid arthritis prognosis, potentially advancing treatments.
A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.