Whitepaper: BioSeek: Economic Impact of BioMAP® Profiling – Bridging the Gap from In Vitro to In Vivo
BioSeek use their BioMAP® Diversity PLUS analysis to provide validation of mechanism of action (MOA) in the discovery phase…
The client identified a novel IL-17 inhibitor as its lead compound to treat an autoimmune disease. Specifically, it had identified the compound in a phenotypic screen of mouse cells and tested it in a rodent model for Collagen-Induced Arthritis. At this point, our client had collected valuable pre-clinical insights about the efficacy of the compound based on cellular and biochemical assays. However, these assays did not provide any insight into the mechanism of action (MOA) of the compound. Our client had already invested two years of preclinical research and up to $2 million in R&D to move the compound to this stage. The client also previously engaged the services of a contract research organization, but the results were uninformative. The client sought a new approach that could yield insights on MOA that may have been missed by earlier studies.
The client hoped to introduce the drug into clinical trials, and this would require validation of MOA in the discovery phase in order to reduce the safety risk from an unknown mechanism. Launching a drug in the international market costs more than $1 billion in annualized costs (DiMasi, J. & Grabowski, H. (2007) Manage. Decis. Econ. 28: 469-479) and requires six to nine years of clinical development. Hence, collecting accurate preclinical data for safety and efficacy with appropriate benchmarks, and knowing the MOA, would position the client to identify a suitable market and develop appropriate clinical trials.
This whitepaper is restricted - login or subscribe free to access
Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.
Why subscribe? Join our growing community of thousands of industry professionals and gain access to:
- quarterly issues in print and/or digital format
- case studies, whitepapers, webinars and industry-leading content
- breaking news and features
- our extensive online archive of thousands of articles and years of past issues
- ...And it's all free!
Related content from this organisation