The quest for accurate target validation

Posted: 9 April 2015 |

Preview of the upcoming foreword in our April issue, written by Sheraz Gul, Vice President and Head of Biology at Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Hamburg, Germany…

The identification and implication of proteins in disease processes is ever increasing as evidenced by the number of peer-reviewed publications citing such links. This is not surprising given the increase in the number of organisations involved in drug discovery outside the pharmaceutical and biotech industry. However, it is often the case that a target is implicated in different diseases with varying levels of confidence depending on the nature of work reported. As a consequence, robust target validation relating to disease association is often lacking and it is not uncommon that further research negates the original hypothesis. Although this offers the opportunity to discover first-in-class drugs, progressing small molecule drug discovery for such targets is often extremely challenging.

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