Pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease: approaches and perspectives

Mitochondrial dysfunction has been widely implicated in the neuronal degeneration in Parkinson’s disease (PD). Mitochondria-targeted protective compounds that prevent or minimise a wide range of mitochondrial defects constitute potential therapeutic strategies in the prevention and treatment of neuronal degeneration in PD.

This review discusses the latest findings in this field obtained in PD patients and in animal and cellular models of PD with focus on the effects of pharmacological agents on mitochondrial biogenesis, fission, fusion, mitophagy machinery, and transcription of endogenous cytoprotective antioxidant enzymes. We also present data concerning the technologies for research and screening of novel bioactive molecules to target mitochondrial dysfunction in Parkinson’s disease.

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