A universal flu vaccine may be in sight
21 September 2018 | By Iqra Farooq (Drug Target Review)
Researchers from Oxford have identified the initial steps on the path towards creating a universal influenza vaccine that could last for life...
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Therapeutics
PD-1 and CTLA4 therapies together could benefit women with ovarian cancer
20 September 2018 | By Iqra Farooq (Drug Target Review)
Women with ovarian cancer could in future benefit from a combined therapy using PD-1 and CTLA-4 as shown through the results of this Phase II trial...
Detecting epigenetic signature may help people stay ahead of IBD
20 September 2018 | By Drug Target Review
Researchers have reported finding on an epigenetic signature in patient cells that appears to predict inflammation risk in Crohn's disease...
NLRP12 protein promotes healthy gut bacteria to curb obesity
20 September 2018 | By Drug Target Review
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
Green tea compound helps siRNA slip inside cells
19 September 2018 | By Drug Target Review
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
Amyloid beta – a good therapeutic target?
19 September 2018 | By Iqra Farooq (Drug Target Review)
Phase III clinical trials for a drug targeting amyloid beta plaques are underway, with results expected in the next two to three years...
Pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease: approaches and perspectives
19 September 2018 | By Iryna Karaban, Iryna Mankovska, Kateryna Rozova, Larysa Bratus, Olga Gonchar
Mitochondrial dysfunction has been widely implicated in the neuronal degeneration in Parkinson’s disease (PD). Mitochondria-targeted protective compounds that prevent or minimise a wide range of mitochondrial defects constitute potential therapeutic strategies in the prevention and treatment of neuronal degeneration in PD.
Np63a should be targeted in squamous cell carcinomas
19 September 2018 | By Iqra Farooq (Drug Target Review)
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
Class of neurological disorders share 3D genome folding pattern
19 September 2018 | By Drug Target Review
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
Structural map of bacterial toxins identified
18 September 2018 | By Iqra Farooq (Drug Target Review)
A three-dimensional structural map of bacterial toxins has been identified for the bacterium Pseudomonas aeruginosa...
Six compounds identified from 70,000 to help eradicate malaria
18 September 2018 | By Iqra Farooq (Drug Target Review)
Researchers from Imperial College London have identified 6 compounds from almost 70,000 that could help to eradicate malaria...
CRISPR used to deliver BChE into cells to protect from lethal cocaine doses
18 September 2018 | By Drug Target Review
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...
Dietary fibre could be key to prevent age related decline in brain functions
17 September 2018 | By Iqra Farooq (Drug Target Review)
Researchers have identified that dietary fibre could be beneficial for older people, to prevent inflamed microglia leading on to cognitive disorders...
Fewer side effects from cancer drugs promised
17 September 2018 | By Iqra Farooq (Drug Target Review)
Researchers from Copenhagen have developed a method of accurately using proteins to track the path of a drug through the body to ensure its safety...
Testosterone replacement therapy could slow the progression of COPD
14 September 2018 | By Drug Target Review
Researchers from Texas University have used data from men with COPD to ascertain that testosterone replacement therapy could be beneficial...
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