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Secondary structures study could lead to making cancer cells vulnerable
Researchers have used machine learning to discover that the two most widespread DNA structures cause genome mutations that lead to cancer.
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Natural antioxidant helps improve immune-based therapies
Scientists have discovered a way to improve immune-based treatments by modulating T cells.
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Crystals mapped to advance treatments for stroke, diabetes and dementia
Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.
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Why do we have no effective treatments for osteoarthritis?
Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4
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Paving the path towards precision medicine
A method to view the immune cell 'landscape' of bowel cancer tumours could pave the way towards more individualised medicine and treatment...
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Machine-learning model to analyse protein sequences
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
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Potential EBV-associated cancer treatment in small molecule inhibitors
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
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Anthelmintic drug niclosamide repurposed to treat Helicobacter pylori
Researchers have repurposed use of niclosamide to treat Helicobacter pylori cell lines, focusing on how it is effective in infection models...
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Genomics to match treatments to pancreatic cancer patients
Genomics could be used to match drugs to patients better, with these genetic signatures also giving an earlier insight into detection of the condition...
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Protein marker in response to brain cancer therapy
An extremely powerful MRI scanner was used to image proteins in the brain of cancer patients and has shown that protein content correlates with treatment...
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Colon cancer pathway discovery could lead to targeted therapies
Researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer...
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Counteracting T-cell exhaustion in CAR-T cancer therapies
Engineered T-cells that target NFAT and Nr4a proteins could help to prevent the exhaustion of T-cells during CAR-T immunotherapy...
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Secret life of antimicrobial peptide revealed through CRISPR
Antimicrobial peptides were found to act against Gram-negative bacteria and certain fungi by working either together or by adding up their individual effects...
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Book mechanism identified as communication method for bacterial toxins
Researchers have identified the mechanism by which highly toxic compounds communicate, and how they use vesicles to be transported...
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MRI sensor to image activity deep inside the brain
A method of imaging calcium activity that is based on magnetic resonance imaging (MRI) could help to image deep within the brain...
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