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Obesity

How GPCR agonists, including antibodies, are shaping the future of metabolic care

4 December 2024 | By Dr Cedric Ververken

Find out how Confo Therapeutics is overcoming challenges in GPCR drug development to create next-gen therapies for metabolic diseases.

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CNIC identifies key mechanism in fat cells to combat obesity

2 December 2024 | By Drug Target Review

CNIC researchers have identified a mechanism in fat cells that helps them safely store excess fat, offering new insights for combating obesity and related metabolic diseases.

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Suppression of neuropeptide F extends longevity in flies

17 October 2024 | By Drug Target Review

The relationship between insulin and ageing in flies could have far-reaching implications for diabetes and obesity drugs for humans.

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Collaboration between Lilly and the UK life science sector

15 October 2024 | By Drug Target Review

Announced at the International Investment Summit, Lilly plan to support early-stage life sciences businesses to develop therapeutics for significant health challenges.

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Mechanism linking obesity to inflammation uncovered

28 August 2024 | By Drug Target Review

This study is first to demonstrate with statistical certainty that human visceral adipose tissue accumulated in the abdominal cavity secretes more extracellular vesicles.

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Discovery of a signalling pathway that activates desire to exercise

21 August 2024 | By Drug Target Review

The study highlights the possible therapeutic significance of targeting the pathway for treating obesity and metabolic disease.

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The promise of therapeutics from molecules within our body

16 May 2024 | By Dr Alla Arzumanyan (SFA Therapeutics), Dr Ira Spector (SFA Therapeutics), Dr Mark A. Feitelson (SFA Therapeutics)

In this article, senior leaders at SFA Therapeutics emphasise the importance of re-establishing homeostasis in drug development approaches.

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Explaining sex differences in adipose insulin resistance

14 May 2024 | By Drug Target Review

Heightened insulin resistance in obese men may elucidate the higher prevalence of type 2 diabetes among these individuals.

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Mesothelial cells in omental adipose tissue hinder adipogenesis

13 May 2024 | By Drug Target Review

The discovery that omental fat has a mechanism to limit adipocyte formation may lead to new treatments for obesity and metabolic disease.

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Evaluating the anti-obesity effects of tocotrienols

19 April 2024 | By Drug Target Review

The new study found T3s treatment exhibited neuroprotective effects in HFSD-fed mice by mitigating oxidative stress.

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Rare genetic variants found to have a large impact on obesity risk

5 April 2024 | By Drug Target Review

Researchers have gained a deeper understanding of the neural biology of obesity, which could offer potential drug targets.

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Scientists elucidate the mechanism behind middle-aged obesity

14 March 2024 | By Drug Target Review

New findings show that age-related MC4R+ cilia shortening causes middle-aged obesity and leptin resistance, which could lead to obesity treatment.

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Improving treatments for rheumatoid arthritis patients

7 February 2024 | By Drug Target Review

Researchers found that resolvinT4 restores protective macrophage biological activities in rheumatoid arthritis patients.

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Direct link between hyperinsulinemia and pancreatic cancer found

31 October 2023 | By Drug Target Review

Excessive insulin levels in people with obesity and type 2 diabetes overstimulates pancreatic cells, initiating disease.

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Study reveals harmful gut bacteria linked to irregular sleep patterns

11 August 2023 | By Taylor Mixides (Drug Target Review)

New Study from King's College London: Irregular Sleep Patterns Tied to Harmful Gut Bacteria.

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Obesity