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Direct link between hyperinsulinemia and pancreatic cancer found
Excessive insulin levels in people with obesity and type 2 diabetes overstimulates pancreatic cells, initiating disease.
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Obesity
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Study reveals harmful gut bacteria linked to irregular sleep patterns
New Study from King's College London: Irregular Sleep Patterns Tied to Harmful Gut Bacteria.
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Are female mice better protected against obesity?
The University of California underwent a mouse study disclosing underlying sex differences in mice for obesity.
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Cancer-killing benefits of popular obesity treatment
Findings from the Republic of Ireland, in relation to GLP-1 obesity treatment showcase its ability to restore the body’s natural cancer-killing defences.
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New drug promotes weight loss in mice
US researchers discover compound that limits weight gain in mice with a high-sugar diet, by lowering the mitochondrial magnesium.
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Preventing diet-induced obesity in mice
Japanese researchers discover the mechanism of inhibition of diet-induced obesity in mice by the glucose-dependent insulinotropic polypeptide
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Protein Grb10 offers a potential new approach for treating obesity
The researchers found that the protein Grb10 promotes leptin activity in the brain, opening the possibility of developing Grb10-based new approaches to treat obesity.
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New drug discovery offers method to identify metabolic condition therapies
Drug-initiated activity metabolomics screening discovers the metabolite myristoylglycine, that converts white fat cells to brown fat cells.
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Closing the diversity gap in genomics
In this article, Drug Target Review’s Ria Kakkad explores the importance of diverse and inclusive samples in genomic studies with Assistant Professor Lindsay Fernández-Rhodes, Pennsylvania State University.
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Extracellular vesicles: a new target for understanding endocrine disorders
Scientists at the Endocrine Society have found extracellular vesicles may offer new insights into treating endocrine disorders.
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Research provides a potential drug target to treat diabetes and obesity
A new study by University of Texas Health Science Center at San Antonio has found that boosting liver mRNAs in obese mice reduces appetite and body weight.
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New study could lead to diabetes treatment with fewer side effects
Researchers from the University of Pennsylvania may have discovered how to eliminate the risk of weight gain from certain diabetes medications by uncovering the difference between two varieties of a protein.
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New target for overeating identified in the brain’s cerebellum
The study uncovered disordered signalling in the brain's cerebellum, offering a novel therapeutic target for Prader Willi syndrome.
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Fruit flies could unveil new genetic targets for obesity treatment
Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
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GLP-1 and GIP receptor agonists reduce mouse obesity in pre-clinical study
Treatment with Viking Therapeutics' dual agonists resulted in mean reductions in body weight of up to 27 percent compared to semaglutide-treated animals.