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This In-Depth Focus reviews the history of cancer treatments, looks at improving the translation of disease biology though phenomics, and considers how to enhance cell bioprocessing through cell-based combinatorial culture.
In this issue: the positive impact of genomics on drug discovery, development and deployment, the confluence of biology and technology, and Artificial Intelligence: harnessing the potential to drive progress in drug discovery promises much for phenotypic drug discovery
A new scientific statement summarises the state-of-the-science of genomic medicine...
How to perform successful long term live cell imaging in a high-content analysis system.
Although readers of Drug Target Review may be more focused upstream of clinical trials in the drug discovery pipeline, the efficacy of clinical trials should also be of interest. Millions of pounds invested in drug discovery in the laboratory could easily go to waste if the clinical trials stage is…
A new diagnostic test developed by researchers at UC San Diego shows promise for detecting pancreatic cancer earlier...
Extension includes new project to phenotype Parkinson’s disease models and the continuation of LRRK2 research.
Addition of high-throughput technologies and expanded pharmacokinetic services enhances existing support for small molecule drug discovery.
Researchers are reporting an innovative new method to screen for potential cancer drugs...
Cancer researchers have measured systematically how efficient molecules are at suppressing the activity of a protein associated with prostate and other cancers...
High levels of cytoskeleton-associated protein 4 (CKAP4) have been identified in the blood of patients with lung cancer.
This article compares and contrasts a commonly used cell viability assay in manual and automated fashion and provides exemplar data from each scenario.
High-throughput screening (HTS) has become an integral part of early stage drug discovery. This article looks at the use of the latest in vitro 3D cell and tissue culture model systems in HTS. We also highlight some of the bottlenecks and attempt a look into our crystal ball to identify…
Researchers have developed a new peptide format that they call double-bridged peptides...
Scientists have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford progeria syndrome...
