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Drug Target Review – Issue 4 2023
21 December 2023 | By
A new Drug Target Review issue is now ready to download! This issue features articles on CRISPR, personalised medicine and screening.
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Targets
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The future of mRNA biology and AI convergence
In the rapidly evolving landscape of mRNA biology and artificial intelligence (AI), Anima Biotech stands at the forefront, a unique approach that reshapes our understanding of diseases and transforms the drug discovery process. mRNA biology holds immense potential with RNAi drugs in the market and mRNA vaccines showing promise, particularly…
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How pathological alpha synuclein causes neuron death
A new finding that pathological alpha-synuclein causes cells to increase protein synthesis suggests new targets for treating PD.
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The first multi-chamber heart organoids developed
The first multi-chamber cardioids derived from hiPSCs have enabled scientists to investigate heart development and defects.
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Disrupting the mechanism pathogens use to infect host cells
New understanding of the communication system between pathogens and host cells provides a way to avoid antimicrobial resistance.
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Navigating the neuroscientific landscape with Dr Judy Illes
In a world grappling with the growing spectre of eco-anxiety and the pressing challenges posed by climate change, Dr Judy Illes, a distinguished figure in the field of neuroscience, sheds light on the role neuroscientists play in contributing to the discourse on environmental issues and their profound impact on individual…
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The influence of the immune system on early human lung growth
Understanding the mechanisms in lung formation could develop new therapeutic approaches for respiratory conditions.
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HIV vaccine may require a strong response from CD8+ T cells
The new findings could help preventive and therapeutic HIV vaccine design and development, and HIV immunotherapy approaches.
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Potential target found for CDKL5 deficiency disorder
Using phosphoproteomics, the calcium channel Cav2.3 was found as a target to treat a type of genetic epilepsy, CDKL5 deficiency disorder.
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New lipid nanoparticles effectively deliver RNA to microglia
LNPs deliver small interfering RNA to the brain’s microglia to combat inflammation related to Alzheimer’s disease.
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New understanding of the TMEJ pathway in cancer
Cancer treatment may be majorly impacted by new findings about the polymerase theta-mediated end joining time DNA repair pathway.
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New method to induce target-specific immune responses
By fusing antigen proteins into an anchor protein, a specific disease could be targeted without the need to purify the antigen.
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Perivascular fibroblasts support glioblastoma tumours
Glioblastomas can resist immunotherapy as perivascular fibroblasts support the creation of an immunosuppressive tumour environment.
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The first major set of genetic associations found in long COVID
PrecisionLife’s Dr Sayoni Das, a computational biologist who leads the research and development of bioinformatics pipelines that generate biological insights from PrecisionLife’s core technology and support drug discovery programmes, details a new study. Using combinatorial analysis, genetic variants associated with long COVID have been identified and, furthermore, it has been…
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New organoid model of neuroendocrine tumours developed
NETs require epidermal growth factor to grow, meaning that inhibiting EGF receptors could treat these types of tumours.