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Issue #3 2017

 

Mass spectrometry imaging in drug discovery

11 September 2017 | By ,

Mass spectrometry imaging allows direct measurement of the molecular composition of a sample. It can be used to image the spatial distribution of exogenous drugs and endogenous metabolites simultaneously over the surface of tissue sections or small biopsy, allowing new insights into both compound efficacy and safety during drug discovery.

Application note: Study of bacterial biofilms using Thermo Fisher Scientific Varioskan LUX multimode reader and EVOS FL Cell Imaging System

11 September 2017 | By , , ,

This note demonstrates the feasibility of combining the Thermo Fisher Scientific Varioskan LUX multimode reader with the EVOS FL imaging system for the fluorescence-based quantification and imaging of bacterial biofilms, especially for drug discovery applications...

Assays In-Depth Focus 2017

8 September 2017 | By

This in-depth focus looks at improving assay techniques to produce more detailed results using crystallography. It also covers some aspects of high-content screening assay development that are critical to successful implementation...