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Lupus flare-ups linked to bacterial growth in gut
US researchers find that recurrent bouts of systemic lupus erythematosus is closely tracked with measurable upticks in growth in the gut of a certain species of bacteria.
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Animal Models
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New immunotherapy combination improves efficacy in animal models of liver cancer
Researchers at the Cima University of Navarra lay the foundations for the application of an immunotherapy combination in patients with the liver cancer: hepatocellular carcinoma.
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Combination therapy effective against canine melanoma
A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.
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Drug helps reduce bacterial antibiotic resistance
US researchers uncover a new drug that reduces the ability of bacteria to develop antibiotic resistance, prolonging the antibiotic effectiveness.
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The genetic modifier approach: identifying the right target for rare diseases
In this article, Dr Vincent Blomen, Senior Director of Target Discovery at Scenic Biotech, takes us through the realm of rare diseases. In the case of most of these diseases, a singular genetic anomaly often reigns supreme, yet its impact on patients can be vastly divergent. Enter modifier genes, the…
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New treatment options for chronic kidney disease
Fresh insights from University of Edinburgh into a protein that causes damage in kidneys and hearts could open up new treatment options for chronic kidney disease.
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Neurons that are responsible for recognition
Researchers from South Korea uncover that neurons in the hippocampus play a crucial role in assigning positive value through interactions with others.
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Scientists create first humanised mouse model for rare genetic disease
German researchers have successfully developed mice with a defected human gene responsible for congenital adrenal hyperplasia (CAH), a rare genetic disease.
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Potential pathway to improved stroke recovery
Japanese researchers identify a protein that reduces inflammation, stimulates neural growth, and improves sensory and motor functions following ischemic stroke in mice.
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Helper T cells may hold key to precision allergy treatment
US researchers have connected a rare T cell called Th9 with treating allergies, testing in mouse models with asthma.
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Reviving T cells to tackle immunotherapy-resistant cancers
US researchers utilise a new approach to immunotherapy, using exhausted T cells that could help overcome treatment resistance in cancers.
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Chances of eliminating HIV infection increased by dual gene-editing method
US researchers suggest that combing a dual gene-editing approach with antiretroviral drugs can eliminate HIV infections in animal models.
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Blocking a microRNA may prevent age-related conditions
Conditions like chronic inflammation, muscle loss and bone loss have an elevated microRNA, US researchers attempted to block this in aged mice.
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Genetics behind facial and skull changes in Down Syndrome mouse model
Progress in identifying the gene responsible for facial and skull changes in mouse model of Down Syndrome, made by UK researchers.
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Organ-on-a-chip device aids the study of thrombosis without animal models
Scientists from the University of Birmingham have developed an organ-on-a-chip-model to better understand the mechanisms of deep vein thrombosis.
