whitepaper
Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
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CRISPR
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
news
CRISPR used to prevent cancers tied to EBV and KSHV
Researchers have discovered a possible path forward in preventing the development of cancers tied to two viruses, including the virus that causes infectious mononucleosis...
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New Cas9 enzyme widens scope for CRISPR genome editing
A team of researchers has discovered a Cas9 enzyme that can target almost half of the locations on the genome, significantly widening its potential application.
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GFAP gene mutation creates tangles in brain cells – cause of neurological disease
A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
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Critical cancer immunity genes identified using genetic barcoding
Genetic barcoding using Pro-codes and CRISPR could be used to identify critical cancer immunity genes to aid future therapeutics...
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Prenatal gene editing used in treating congenital disease before birth
Researchers show the first example of a base-editing tool to treat a disease in utero in animal models...
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Np63a should be targeted in squamous cell carcinomas
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
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CRISPR used to deliver BChE into cells to protect from lethal cocaine doses
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...
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Expert view: Assays to measure the potency of therapeutic antibodies used in combination with other drugs for Immuno‑Oncology treatments
Growing evidence reveals that using single immunotherapies to treat oncological disorders may lead to cancer-killing T-cell overdrive,initiating life-threatening autoimmune reactions including cytokinestorm; also known as hypercytokinemia or Cytokine Release Syndrome(CRS). Recently, checkpoint blockade using anti-programmed cell death1 (anti-PD-1) inhibitors became a prevalent approach for stimulatinganti-tumour immune system.
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Complex biology for the precision medicine era: re-thinking the drug discovery process
Complex biology is a discipline acknowledging that performing biological experiments in vitro should take account of the complexity of the biological context.1 While this may be a noble aim, it has proven difficult to incorporate these elements into the drug discovery process, especially at the high-throughput screening (HTS) stage.2
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CHAOS approach to antibiotic resistance
Researchers have developed a new CHAOS method to combat antibiotic resistance, using CRISPR DNA modification techniques...
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CRISPR technique skips over portions of genes that can cause disease
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
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CRISPR-Cas9 used to correct sickle cell–causing mutation
Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...
