Potential new treatment options for KSHV-associated cancers
Treatment with Palbociclib and a compound targeting CAD increased survival to 100 percent for selected lymphoma cell lines.
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Treatment with Palbociclib and a compound targeting CAD increased survival to 100 percent for selected lymphoma cell lines.
Researchers elucidate the significant role of CDX2 in regulating stemness and differentiation, particularly in the proximal colon’s epithelial cells. This research encourages new combinations of existing drugs, that inhibit both the BRAF and KRAS genes, to be explored.
PrecisionLife’s Dr Sayoni Das, a computational biologist who leads the research and development of bioinformatics pipelines that generate biological insights from PrecisionLife’s core technology and support drug discovery programmes, details a new study. Using combinatorial analysis, genetic variants associated with long COVID have been identified and, furthermore, it has been…
Researchers from Tokyo Tech's World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum.
Findings from the Republic of Ireland, in relation to GLP-1 obesity treatment showcase its ability to restore the body’s natural cancer-killing defences.
US researchers find combination of chloroquine and venetoclax promotes cancer cell death in mouse models with acute myeloid leukaemia (AML).
US researchers have studied (cannabidiol) CBD as a solution for opioid overdoses, instead of a popular opioid antidote.
Scientist and doctors from Spain have uncovered that oxaliplatin, a chemotherapy drug used to treat colon and rectal cancer, avoids the side effects this treatment can have on normal tumour cells, including potential chemotherapy resistance
The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies.
In an ongoing discovery programme, a chemical-creation platform is being revealed – based on cubic molecules – that could help breathe new life into tired drugs.
US scientists suggest that anti-angiogenesis drugs could improve the function and delivery of CAR-T cell therapy.
A US pre-clinical study investigating the antidepressant: MAP4343, discovered it reduced alcohol intake in a mouse model of alcoholism.
Chronic pain often leads to depression, which US researchers have potentially solved using a mechanism involved with ketamine.
The researchers used single-nuclear sequencing and advanced three-dimensional glass imaging of mice to find new drug targets for non-alcoholic fatty liver disease.
Dutch researchers, using optogenetic approaches and an asthma drug, discovered that memory loss from sleep deprivation can be retrieved.