product
ProteinSimple Peggy Sue
3 December 2015 | By ProteinSimple
Simple Western™ system that can separate, analyse and quantify proteins based on either size or charge…
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
article
The challenges associated with ‘de-risking’ early-stage therapeutic targets
The pharmaceutical industry is searching for novel drug targets that could produce the next generation of ‘first-in-class’ therapeutic agents. The challenge for academia is to identify and translate such targets and to provide starting points and confidence in the underlying science. The aim should be to generate evidence that modulation…
product
ProteinSimple NanoPro 1000
2 December 2015 | By ProteinSimple
Simple Western™ system for the characterization of post-translational protein modification by the detection of charge isoforms...
news
CFTR interacts with the wrong partners in cystic fibrosis
30 November 2015 | By Victoria White
By removing these interactions, the researchers partially restored the protein’s normal function. The findings suggest that therapies could one day treat the root cause of cystic fibrosis, not just the symptoms...
webinar
Genomic support for target selection and validation in drug development: design of a new genotyping array
22 November 2015 | By Illumina
In this webinar, we focus on the use of microarray technology in drug development...
news
TIGIT identified as new target for immuno-oncology therapies
17 November 2015 | By Victoria White
Antibodies against TIGIT could improve the function of the DNAM-1 protein, thereby improving the ability of natural killer cells to destroy tumour cells...
news
GPR3 identified as a new target for Alzheimer’s disease treatment
15 October 2015 | By Victoria White
Researchers have determined that the protein GPR3 might play an important role in alleviating the cognitive deficits of 'amyloid plaques'...
whitepaper
App Note: Easy Particle Analysis for Viscous Samples with MFI
In this application note, learn how the manual MFI 5000 performs accurate particle analysis for viscous protein therapeutics, offering size, count and morphology...
news
UCL and Takeda to identify targets for neurodegenerative diseases
14 October 2015 | By Victoria White
The three-year collaboration will focus on mechanistic approaches for the identification of genes or signalling pathways that modify neurodegenerative disease processes affecting neuronal health...
whitepaper
App Note: Achieving 21 CFR Part 11 Compliance with the iCE3
Rapid analysis, platform methods and easy method development make the iCE3 ideal for analyzing biologics...
whitepaper
App Note: Computer-aided Assay Development for Charge Heterogeneity Analysis by iCE
Due to protein therapeutic complexity, techniques like isoelectric focusing have become indispensable tools in evaluating biologic preparations...
whitepaper
App Note: Fast, Multi-sample Particle Analysis Using MVSS 4.0
Micro-Flow Imaging™ (MFI™) has new MVSS 4.0 software to classify particles across many biopharmaceutical samples easily and instantaneously...
whitepaper
App Note: Comparability Study of Manual and Automated Particle Characterization with MFI
In collaboration with Takeda, Micro-Flow Imaging with the Bot1 Autosampler automated manual methods for monitoring biopharmaceutical quality/safety...
whitepaper
App Note: Easy Transfer of Your Traditional Western Blot to Wes
Wes™ builds on over a decade of Simple Western development and makes running a Western even more simple...
news
Nav1.5 identified as potential therapeutic target for breast cancer
9 October 2015 | By Victoria White
When using the shRNA in breast cancer cells, Nav1.5 levels were 'knocked down', resulting in reduced tumour growth rates and metastasis...
