news
Researchers develop tool that could improve liquid biopsy
A US study has overcome a major obstacle in cell-free DNA (cfDNA) testing or liquid biopsy, offering promising advancements in disease diagnosis and monitoring.
List view / Grid view
Molecular Biology
news
Molecular biology behind memory development in early childhood
Researchers from Canada develop a greater understanding about the molecular mechanisms for memory development in early childhood.
news
Researchers develop Raman imaging probes for detecting enzyme activities
Japanese researchers have developed activatable Raman probes based on 9CN-rhodol, offering a promising tool for detecting multiple enzyme activities in heterogeneous biological tissues. This new molecular design strategy allows for highly specific and sensitive detection of enzyme activities, offering potential applications in disease diagnosis and biological research.
news
Novel study suggests alternatives to aspirin with fewer side effects
The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies.
article
Assay performance and the Z’-factor in HTS
Matthew Lloyd from the University of Bath reveals the importance of the Z-factor and Z’-factor in high-throughput screening, and how they can be used to determine assay performance, perform quality control on the screen, and identify active compounds.
article
De-risking drugs in multiplex assays before progressing to clinical trials
Sheraz Gul, Head of Assay Development and Drug Repurposing at the Fraunhofer Institute, discusses the importance of performing comprehensive multiplex spatial and temporal profiling of drugs in pre-clinical research to decrease the risk of potentially undesirable events in later clinical studies.
news
‘Chemical cube’ tools for building new drugs
In an ongoing discovery programme, a chemical-creation platform is being revealed – based on cubic molecules – that could help breathe new life into tired drugs.
news
Enzyme opens door to new therapeutic targets for cellular stress
The activity of enzyme ATE1, as seen by US researchers, flags misfolded proteins for destruction and is enhanced by binding iron-sulphur clusters.
article
Understanding molecular mechanisms behind breast cancer
Oestrogen receptors play a crucial role in breast cancer. By making them therapeutic targets, oestrogen can be regulated with the aim to prevent breast cancer.
news
New insights on the structural biology of medical cannabis
French researchers underwent a structural study showing that THC cannabinoids inhibit a human enzyme called autotaxin.
article
Women in STEM with Dr Jane Osbourn
Drug Target Review’s Ria Kakkad recently spoke with Dr Jane Osbourn about her experience as a woman in STEM.
article
Activity-directed synthesis: a structure-blind, function-driven molecular discovery approach
An autonomous strategy for molecular discovery could enable the exploration of a far broader chemical space than is possible with conventional approaches. In this article, Niamh Morris from Rosalind Franklin Institute outlines why activity-directed synthesis (ADS) could be the answer, providing examples of how this technique has the potential to…
article
Drug Target Review Screening ebook 2022
In this ebook are articles on how artificial intelligence can be used to identify drug candidates, data-lead screening models and autonomous strategies for molecular discovery.
news
New method to label proteins could help track disease
Scientists have developed a new method to study the proteins released by cells, which could lead to the development of new tools to track diseases including cancer.
news
New study reveals the exact molecular structure of an IgM-type B-cell receptor
Using cryo-EM, the researchers found that the B-cell receptor interacts with further receptors, thus controlling its signal transduction.
