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Application note: Direct and Competitive Live Cell Antibody Binding
Utilizing Advanced High-Throughput Flow Cytometry to Quantify Direct and Competitive Live Cell Antibody Binding
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Protein
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Controlling MYC’s hyperactivity with a peptide compound
A novel peptide can suppress MYC by binding directly to it with sub-micro-molar affinity, advancing cancer drug development.
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Unique self-activating proteins for drug discovery
Explore cutting-edge hit-to-lead insights through exclusive interviews and studies by leading experts in the field.
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Allosteric control sites in KRAS protein found
The first complete control map for any protein has been made for KRAS, and four potential drug targets have been discovered.
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The loading mechanism of bacteria injectisomes is now understood
Proximity labelling and single-particle tracking demonstrated that effectors in bacteria bind to mobile injectisome components.
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New technology to effectively regulate gene expression
A new strategy enables researchers to be more precise in the control of gene expression of a therapeutic protein.
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How pathological alpha synuclein causes neuron death
A new finding that pathological alpha-synuclein causes cells to increase protein synthesis suggests new targets for treating PD.
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AI system produces binding proteins using limited target information
New software can make protein molecules that bind with high affinity and specificity to many biomarkers, including human hormones.
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Potential therapeutic target found for the Zika virus
A discovery about Zika’s enzyme, NS2B-NS3, offers promise for therapeutic targets for Zika and other flaviviruses.
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eBook: A Microscopy Guide For Spatial Biology
In this eBook, discover how to better understand tissue landscapes with different microscopy techniques including multiplex imaging.
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Investigating the genetic changes of the DDX3X gene
Using saturation genome editing, researchers have created a map of disease-causing mutations for neurodevelopmental disorders and cancer.
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Mutated DECTIN-1 and its implications for autoimmune disease
A discovery about the mutated protein DECTIN-1, that limits the production of T regulatory cells, could lead to more effective drugs.
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Discovery of molecular pathway could target lung cancer
New findings about how RBM10 inhibits lung cancer growth offers potential for an anti-cancer drug and more personalised treatment.
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Potential therapeutic target for ventricular fibrillation found
A signalling mechanism for ventricular fibrillation involving the stress kinases p38γ and p38δ has been discovered.
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New algorithm identifies a novel CRISPR-Cas system
Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.
