Researchers investigating childhood leukaemia have discovered that increasing MLL gene expression in iPSCs drives hematopoietic stem cell production, so could be the target of new therapies.
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Researchers have revealed that astrocytes contribute to reward signalling in the brains of mice, so could be a novel target to treat drug addiction.
A possible new avenue for treatment of Acute Myeloid Leukaemia (AML) has opened up after US scientists pinpoint how the cancer spreads using excessive amounts of vitamin B6.
Using brain scans, a study has shown that schizophrenia patients have lower levels of the protein SV2A in their brains which presents a drug target.
A team of scientists in the United States has successfully used a drug, which blocks AHR receptors, to prevent and treat obesity in mice. Their findings have spurred further research into the receptors’ association with diet and the gut microbiome.
Scientists have created the first lab-dish models of the cellular clock, where each 'tick' stimulates the formation of the vertebra, which uses stem cells derived from adult human tissue.
A study has identified a protein complex elevated in PTSD patients and developed a peptide to disrupt it, preventing the recall of fear memories in early tests and paving the way for new therapies.
A new process for producing organoids allows researchers to explore intestinal epithelium in isolation and could allow for the development of improved targeted treatments of diseases.
It has been discovered that cognitive functions such as memory and learning in old mice are improved with more stem cells and neurons.
Researchers have found inhibiting vascular endothelial growth factor A (VEGFA) signalling can mediate psoriasis development in the epidermis and could be a potential target for novel therapies.
Researchers have discovered that type 1 diabetes patients have low levels of growth differentiation factor 15 (GDF15) in their pancreatic β cells, unlocking a potential alternative to life-long type 1 diabetes disease management.
PPP2R2A gene allele deletion in prostate cancers promotes the uncontrolled division of cells, reinstatement of its protein causes cancer cell death, so could provide a new therapeutic option.
A study has demonstrated the success of new compounds that prevent FOXM1, a transcription factor, from increasing cancer proliferation.
A murine study found histone deacetylase 3 (HDAC3) inhibitors reverse epigenetic changes caused by CREBBP mutations found in lymphomas and could be developed into a novel therapy.
Researchers have demonstrated the success of a new single-particle method of studying the surface of viruses, which could improve vaccine purification and the development of gene therapies.