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Dysfunctional insulin release mechanism identified
A mechanism has been identified which regulates the release of insulin from β-cells and could be used to develop new treatments for type 2 diabetes.
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Methodology developed to genetically modify lab mice and human cells
A method designed to genetically alter laboratory mice can also be used to produce personalised animal models of an aggressive type of malignant brain cancer in children.
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Study reveals neuronal role in glioblastoma growth and how to prevent it
Researchers have discovered neurons send electrical signals to glioblastoma tumours, causing them to grow but have also identified methods of prevention in models.
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New target for regulating mitochondria during stress identified
A new target has been identified for the treatment of heart failure, heart attack, stroke and neurodegeneration.
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Vital cell metabolic pathway regulator identified by study
A study has revealed that the mitoNEET protein controls a metabolic and functional gateway on mitochondria, which could provide a drug target for cancer.
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Study reveals how to make pancreatic cancer chemotherapy more effective
Researchers have shown that blocking a particular enzyme causes chemotherapy to become more effective against pancreatic cancers in pre-clinical studies.
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CRISPR used to treat Duchenne muscular dystrophy in mice
A study has shown that CRISPR can be used as a regenerative technique to treat Duchenne muscular dystrophy, which could be developed as a therapeutic option for humans.
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New technology developed to screen for Huntington’s treatments
Researchers have created a new technology which enabled them to discover more about the causes of Huntington’s disease and which can be used to test drugs.
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Short peptides discovery could lead to new treatments for Alzheimer’s
The memory of mice with Alzheimer's greatly improved after they were injected with two newly discovered short peptides.
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Therapeutic antibodies in cancer therapy
Monoclonal antibodies have shown great promise in the treatment of various cancers. This article discusses how therapeutic antibodies are produced and the various treatment strategies that are currently being adopted.
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New mechanism of controlling fat production revealed
A new study has shown a new mechanism of controlling fat production in the body which could lead to new therapies to treat obesity.
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Slowing progression in Parkinson’s
Currently, there is no licensed treatment to slow or stop the progression of Parkinson’s disease. However, a team at Sheffield University in the UK are currently working to identify compounds that target the dopaminergic brain cells affected by the disease. Nikki Withers speaks to Dr Heather Mortiboys to hear how…
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Designing proteins from scratch with computer science
Marc Baiget-Francesch highlights interesting developments in the field of protein drug design and explains how continual software improvements are speeding up the process.
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Researchers explain how lymphoma cells metastasise to the brain
Chronic inflammatory processes in ageing brains lead to lymphoma cells that have entered the brain tissue being retained.
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Transplanted brain stem cells survive without anti-rejection drugs in mice
An experiment with mice has successively blocked the immune system's T cells from killing transplanted cells.