Microglia protect sensory cells needed for vision after retinal detachment
19 June 2018 | By Drug Target Review
New research shows that microglia, immune cells of the brain and retina, play a protective role in response to retinal detachment...
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Research & Development
The loss of CDK12 pinpoints to a new sub-type of prostate cancer
15 June 2018 | By Drug Target Review
Tumours with alterations in the CDK12 gene were more responsive to immunotherapy, suggesting precision medicine approach...
Genetically engineered bacteria show promise as a new treatment for constipation
15 June 2018 | By Drug Target Review
Researchers have genetically engineered bacteria as a potential new treatment for constipation, the finding is significant in part because there are few approved constipation remedies on the market...
Cancer protein NEDD9 plays a critical role in PAH
14 June 2018 | By Dr Zara Kassam (Drug Target Review)
Study identifies cancer protein as a target for treating fibrosis of the lung arteries with direct implications for patients with pulmonary arterial hypertension...
Alpha-synuclein clumps promote Parkinson’s progression
14 June 2018 | By Dr Zara Kassam (Drug Target Review)
Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease...
Artificial gene defect reveals target to fight genetic disease
13 June 2018 | By Drug Target Review
Scientists have deployed a novel genetic screen to search for synthetic viable interactions on special lines of Fanconi Anaemia-defective cells...
ANT1 mutation links bipolar disorder to mitochondrial disease
12 June 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers have reported that mitochondrial dysfunction affects the activity of serotonergic neurons in mice with mutations of ANT1...
Streamlining drug discovery assays for cancer and cardiovascular disease
11 June 2018 | By PerkinElmer
For lead optimisation, target-based assays are still the most affordable means of rapidly performing fast iterations and remain core to screening. However, the desire for biological relevance is driving ongoing growth in cell-based assays.
Transforming translational research: CANscriptTM – a better predictive model for oncology
8 June 2018 | By Mark Paris
This webinar focused on a recent study evaluating a cohort of head and neck squamous cell carcinoma (HNSCC) patient tumours treated with anti-PD1 using CANscript™.
E06 antibody blocks inflammation from hardened arteries and liver disease
8 June 2018 | By Dr Zara Kassam (Drug Target Review)
Study uncovers new potential therapeutic approach for a number of diseases linked to inflammation, including atherosclerosis, aortic stenosis and hepatic steatosis...
ISSCR 2018 to highlight research driving new discoveries and advances in regenerative medicine
8 June 2018 | By ISSCR
Progress in stem cell research and its translation to medicine is the focus of the International Society for Stem Cell Research annual meeting 20-23 June at the Melbourne Convention & Exhibition Centre in Melbourne, Australia.
SMCHD1 protein found essential to X chromosome inactivation
8 June 2018 | By Dr Zara Kassam (Drug Target Review)
The structural protein is required for the chromosome to adopt a conformation that suppresses gene expression...
Scientists create ‘genetic atlas’ of proteins in human blood
7 June 2018 | By Drug Target Review
Researchers have created the first detailed genetic map of human proteins...
ImmunoPET imaging noninvasively pinpoints colitis inflammation
7 June 2018 | By Drug Target Review
A novel PET imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease...
The role of biomaterials in stem cell-based regenerative medicine
6 June 2018 | By Laura Goldie - Head of Technical Services - Biogelx Ltd.
Despite their vast therapeutic potential in such areas as cell therapy and tissue engineering, stem cells have yet to live up to their original hype and demonstrate widespread clinical success.
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