news
Changes in RNA splicing: a new mechanism for genetic risk in schizophrenia
New research has identified sections of DNA associated with altered regulation of gene expression underlying schizophrenia.
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webinar
Vertical integration of CRISPR/Cas9 in drug discovery
10 February 2017 | By Charles River
In this webinar, Charles River discuss the utilisation of CRISPR/Cas9 technology in drug discovery, with an emphasis on generation of in vitro models for high-throughput screening, and creating new mouse models...
article
Valid biomarker signatures from liquid biopsies – how to standardise NGS
The advent of next-generation sequencing (NGS) techniques has revolutionised transcriptomics research and opened numerous avenues for scientific and clinical applications. While reverse transcriptase quantitative real-time polymerase chain reaction (RT-qPCR) is still considered the gold standard of gene expression analysis, its high throughput, single-nucleotide resolution and ever-plummeting costs have made NGS…
news
Programmable RNA vaccines effective against Ebola and influenza
4 July 2016 | By Victoria White, Digital Content Producer
MIT engineers have developed easily customisable RNA vaccines that can be manufactured in one week and have shown efficacy against ebola and H1N1 influenza...
news
Storm Therapeutics secures £12 million in series A funding
28 June 2016 | By Victoria White, Digital Content Producer
Storm Therapeutics has secured £12 million in series A funding to identify small molecular drugs that target RNA-modifying enzymes...
article
The next revolution in stratified medicine: molecular phenotyping with metabolomics
The study of biochemistry provides molecular insights into how the human population ages, how diseases commence and progress, how molecular changes relate to disease remission and relapse, and how humans respond to treatments...
article
Inhibition of RNA-containing viruses by artificial RNases
The toxicity and antiviral properties of 24 low-molecular-weight artificial RNases (artRNases) including peptides, peptidomimetics, N-alkyl-substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) and a silver (I) complex with cystine were analysed for viruses containing single-stranded and double-stranded genomic RNA (the tick-borne encephalitis virus; TBEV and the influenza virus, respectively) in vitro and in vivo by…
news
Compound erases RNA defect that causes spinocerebellar ataxia type 10
1 June 2016 | By Victoria White, Digital Content Producer
Scientists have created a drug candidate that attacks and neutralises the RNA structure that causes spinocerebellar ataxia type 10 (SCA10)...
article
Finding a cure for neglected tropical diseases with cell-based assays
Neglected tropical diseases pose a significant threat to public health and affect nearly one billion people in tropical and sub-tropical regions throughout the world. There is a pressing need to identify new therapeutics for NTDs and many developed nations are participating in drug discovery efforts...
news
The practicalities of targeted cell delivery: senior scientists gather in London to explore the latest in RNA Therapeutics
8 February 2016 | By SMi Group
SMi will open its doors to host RNA Therapeutics 2016 in just 1 week on 15th and 16th February in Central London...
news
Non-coding RNA helps suppress breast cancer
2 February 2016 | By Victoria White
A team of scientists from Bath, Cambridge and the USA has identified a piece of non-coding RNA that stops cells turning cancerous...
news
AstraZeneca and Moderna enter mRNA therapy collaboration
11 January 2016 | By Victoria White
mRNA-based therapies are an innovative treatment approach that enables the body to produce therapeutic protein in vivo, opening up new treatment options for a wide range of diseases...
news
Exon skipping demonstrates success in severe form of muscular dystrophy
13 October 2015 | By Victoria White
An RNA editing technique called "exon skipping" has demonstrated preliminary success in treating Limb Girdle Muscular Dystrophy Type 2C in a new study...
news
Scientists create immunity to E. histolytica by silencing genes
17 September 2015 | By Victoria White
The new technique could be used to explore genetic mechanisms of resistance in the field of infectious disease and lead to new therapies...
news
UCLA scientists discover therapy that can suppress ulcerative colitis
24 July 2015 | By Victoria White
UCLA scientists have discovered a microRNA-214 inhibitor that has the ability to suppress the development of ulcerative colitis...
