Researchers develop screening platform to detect new antibiotics

12 February 2020 | By Victoria Rees (Drug Target Review)

A new technology developed by scientists combines small molecule screening methods with machine learning algorithms to identify novel antibiotics that inhibit ribosomes.

Antiviral compound could be used to fight influenza

22 January 2020 | By Rachael Harper (Drug Target Review)

A study in mice has found that a compound modelled on a protein found in bananas safely protects against multiple strains of the influenza virus.

Industry collaborate to screen existing drugs to repurpose for cystic fibrosis

17 January 2020 | By Drug Target Review

In an effort to address some of the more serious untreatable infections encountered by patients with cystic fibrosis, Calibr will collaborate with the Cystic Fibrosis Foundation on a two-year project.

SVC112 molecule reduces effects of cancer stem cells with little toxicity

9 January 2020 | By Victoria Rees (Drug Target Review)

A study has shown that the SVC112 molecule can prevent cancer stem cells from producing more tumour cells in cell lines and mice, with no impact on healthy cells.

Five recent drug target discoveries for pancreatic cancer

11 December 2019 | By Hannah Balfour (Drug Target Review)

This article highlights some of the most recent drug target discoveries that could be used to develop and design a treatment for pancreatic cancer.

Researchers must not rely on generic online searches for chemical probes, study finds

3 December 2019 | By Victoria Rees (Drug Target Review)

The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.

Researchers discover potent new antimicrobial molecule

25 November 2019 | By Victoria Rees (Drug Target Review)

A compound that has antimicrobial properties has been found by researchers, which could be used to combat drug-resistant infections.

SEL120: a promising CDK8 kinase inhibitor

28 October 2019 | By Victoria Rees (Drug Target Review)

A novel CDK8 inhibitor has been developed by scientists at Ryvu Therapeutics. Dr Krzysztof Brzozka showcases this molecule and explains the R&D behind it.

New compound keeps cells alive and functioning in a healthy state

7 October 2019 | By Rachael Harper (Drug Target Review)

A world-first compound that can keep cells alive and functioning in a healthy state could be revolutionary for medical emergencies.

Short peptides discovery could lead to new treatments for Alzheimer’s

18 September 2019 | By Rachael Harper (Drug Target Review)

The memory of mice with Alzheimer's greatly improved after they were injected with two newly discovered short peptides.

Researchers explain how lymphoma cells metastasise to the brain

17 September 2019 | By Rachael Harper (Drug Target Review)

Chronic inflammatory processes in ageing brains lead to lymphoma cells that have entered the brain tissue being retained.

Optofluidic chip platform developed for single molecule analysis

19 August 2019 | By Rachael Harper (Drug Target Review)

A new platform has enabled an unprecedented level of control over individual molecules and particles on a chip for high-throughput analysis.

Enzo Life Sciences

Researchers identify chemotherapy-enhancing molecule

10 June 2019 | By Victoria Rees (Drug Target Review)

A new study has found a small molecule which prevents cancer cells from mutating and becoming resistant to chemotherapy.

Hit-to-lead discovery at a nonprofit research institute

7 February 2019 | By Anthony Pinkerton

Small molecule drug discovery has long been the domain of pharmaceutical companies, and that’s not likely to change anytime soon. But there’s a cadre of universities and nonprofit research institutes that have embraced drug development at its earliest stages, in some cases identifying and optimising compounds that target possible disease-driving…