Researchers identify chemotherapy-enhancing molecule
10 June 2019 | By Victoria Rees (Drug Target Review)
A new study has found a small molecule which prevents cancer cells from mutating and becoming resistant to chemotherapy.
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Small molecule
Hit-to-lead discovery at a nonprofit research institute
7 February 2019 | By Anthony Pinkerton
Small molecule drug discovery has long been the domain of pharmaceutical companies, and that’s not likely to change anytime soon. But there’s a cadre of universities and nonprofit research institutes that have embraced drug development at its earliest stages, in some cases identifying and optimising compounds that target possible disease-driving…
Webinar highlights: Integrated fragment based approach reveals enzymatic inhibitors with potential therapeutic application
10 December 2018 | By NanoTemper Technologies
This webinar, held on 25 October 2018, presented the results from integrated fragment-based approaches for Indoleamine 2,3 dioxygenase 1 (IDO1), an enzyme widely recognised as a drug target for the development of immunotherapeutic small molecules in oncology, unveiling the first ligands able to modulate non-catalytic signalling.
Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies
7 December 2018 | By Bio-Techne
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
Immunoassay developed to detect small molecules
6 December 2018 | By Drug Target Review
An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...
Webinar highlights: Cell-based and biochemical high-throughput screening in 1536-well plates
5 December 2018 | By BMG Labtech GmbH
The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.
Expert view: High-throughput screening – make an impact by removing barriers
5 December 2018 | By Michael Kowalski (Global Project Manager at Beckman Coulter)
For drug discovery and biomarker research, screening campaigns are employed to identify potential new treatments for diseases and to answer questions that remain unknown in the scientific community.
Under the microscope: CROs and microplate reader requirements
4 December 2018 | By BMG Labtech GmbH
Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
Cell-based and biochemical high-throughput screening in 1536-well plates
30 October 2018 | By BMG Labtech GmbH
In this webinar, we presented two examples of HTS in 1536-well plates, a screen for protein-protein interactions and a cell-based luciferase reporter assay.
Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application
25 October 2018 | By NanoTemper Technologies
In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...
PIEZO2, a molecular target for neuropathic pain
11 October 2018 | By Drug Target Review
Scientists at Scripps Research have identified the molecule in neurons responsible for tactile allodynia, a protein called PIEZO2...
NLRP12 protein promotes healthy gut bacteria to curb obesity
20 September 2018 | By Dr Zara Kassam (Drug Target Review)
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
Green tea compound helps siRNA slip inside cells
19 September 2018 | By Drug Target Review
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
ELRIG UK Drug Discovery 2018 Event
19 September 2018 | By ELRIG
ELRIG’s (European Laboratory Research & Innovation Group) Drug Discovery meeting, will take place at ExCeL, London, UK, located in the heart of the city, from 9 -10 October 2018...
Small molecule factors found to influence age-related bone deterioration
18 September 2018 | By Drug Target Review
Scientists in the U.S. have reported findings about the mechanisms that contribute to the experience of weaker bones with age.
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