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7 February 2019 | By Anthony Pinkerton
Small molecule drug discovery has long been the domain of pharmaceutical companies, and that’s not likely to change anytime soon. But there’s a cadre of universities and nonprofit research institutes that have embraced drug development at its earliest stages, in some cases identifying and optimising compounds that target possible disease-driving…
10 December 2018 | By NanoTemper Technologies
This webinar, held on 25 October 2018, presented the results from integrated fragment-based approaches for Indoleamine 2,3 dioxygenase 1 (IDO1), an enzyme widely recognised as a drug target for the development of immunotherapeutic small molecules in oncology, unveiling the first ligands able to modulate non-catalytic signalling.
7 December 2018 | By Bio-Techne
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
6 December 2018 | By Drug Target Review
An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...
5 December 2018 | By BMG Labtech GmbH
The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.
5 December 2018 | By Michael Kowalski (Global Project Manager at Beckman Coulter)
For drug discovery and biomarker research, screening campaigns are employed to identify potential new treatments for diseases and to answer questions that remain unknown in the scientific community.
4 December 2018 | By BMG Labtech GmbH
Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
30 October 2018 | By BMG Labtech GmbH
In this webinar, we presented two examples of HTS in 1536-well plates, a screen for protein-protein interactions and a cell-based luciferase reporter assay.
25 October 2018 | By NanoTemper Technologies
In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...
11 October 2018 | By Drug Target Review
Scientists at Scripps Research have identified the molecule in neurons responsible for tactile allodynia, a protein called PIEZO2...
20 September 2018 | By Dr Zara Kassam (Drug Target Review)
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
19 September 2018 | By Drug Target Review
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
19 September 2018 | By ELRIG
ELRIG’s (European Laboratory Research & Innovation Group) Drug Discovery meeting, will take place at ExCeL, London, UK, located in the heart of the city, from 9 -10 October 2018...
18 September 2018 | By Drug Target Review
Scientists in the U.S. have reported findings about the mechanisms that contribute to the experience of weaker bones with age.
17 September 2018 | By BMG Labtech GmbH
Due to the crucial role of G protein-coupled receptors (GPCRs) in mediating cellular responses to external stimuli, these receptors have been and will remain a prime focus for medical research and the pharmaceutical industry for many years to come. Their importance is especially highlighted by the statistic that 30-50% of…
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