whitepaper

Whitepaper: InCELL target engagement assays

Posted: 6 October 2016 | | No comments yet

Monitoring cellular drug penetration and drug-target interaction enables assessment of compound efficacy and confirmation of mode of action…

Monitoring cellular drug penetration and drug-target interaction enables assessment of compound efficacy and confirmation of mode of action. InCELL Hunter™ and InCELL Pulse™ cellular compound target engagement assays provide the ability to confirm compound cell entry and target binding.

In addition, these assays are designed for screening inhibitors, validating hits identified in biochemical assays, measuring cellular EC50 values, and ranking compounds all in the native cellular environment. These simple binding assays require no custom chemical tracer or antibody reagents and provide a convenient solution when functional assays are difficult or unavailable.

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