Application note: Multiplexed automated imaging assay for cardiotoxic compounds using the ImageXpress Pico system

There is an increasing need to expand the variety and complexity of cell-based assays for biologic research and drug discovery.

Stem cell-derived cells and tissues have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safety assessment. In this study, Molecular Devices scientists used human induced pluripotent stem cell (iPSC)-derived cardiomyocytes to develop functional and morphological readouts for testing effects of different compounds in a multi-parametric assay format, using the ImageXpress Pico Automated Cell Imaging System.