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NGS: empowering infectious disease research beyond reality

Pushpanathan Muthuirulan & Pooja Sharma explain how high-throughput next-generation sequencing (NGS) technologies are revolutionising our ability to characterise infectious diseases at genomic, transcriptomic and epigenetic levels…

NGS technology can be used to describe the microbiome in health and diseases states, and it has helped to identify virulence genes for pathogenicity, driven insights into genetic difference among related pathogens, enabled development of diagnostic tools for discrimination among specific strains, revealed mechanisms of host resistance, and also provided comprehensive understanding of host-microbe interactions in infectious disease progression. This article discusses the benefits and challenges of using NGS in infectious disease diagnosis.

Next-generation sequencing (NGS) technology has revolutionised the diagnosis and treatment of infectious diseases. The standard long-time approach of culture-based testing for the diagnosis of infectious diseases is still in use. However, this approach has several limitations including the requirement for dedicated trained staff and intrinsic inefficiency in the propagation of certain…

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