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Radiochemistry and drug synthesis ‘in a flash’

Conventional methods for radiolabelling proteins are time consuming and difficult to automate. In this article, Jason P. Holland discusses how combining photochemistry with radiochemistry enables development of radiolabelled proteins far more quickly and easily – literally in a flash of light.

antibodies

Radiopharmaceuticals are a cornerstone of modern nuclear medicine, but the constraints of working with radioactivity mean that these advanced technologies are often limited to places that can produce radioactive drugs in-house. The exquisite affinity, selectivity and pharmacokinetic properties of monoclonal antibodies (mAbs) and related biologically-active fragments or biosimilars make them attractive starting points for developing targeting agents for immuno-positron emission tomography (immuno-PET) and radioimmunotherapy (RIT). However, for many small-to-medium sized medical centres, options for radiopharmaceutical production are limited due to the complexity of production and associated high costs. Alternative chemical routes that simplify the production of radiolabelled antibodies are the key to improving access.











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