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A promising new treatment strategy for hepatoblastoma
A combination therapy of vincristine, irinotecan and panobinostat, tested in high-risk, relapsed or refractory HB spheroids, decreased tumour marker levels.
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Cancer research
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Insights into cellular therapies for cancer treatment
Many exciting developments are expected to take place in immunotherapy and oncology in the next few years. We had the privilege of discussing the opportunities of various cell therapies with Dr Suresh Nair, Physician in Chief, who elucidates how Lehigh Valley Topper Cancer Institute is directing research towards better treatments,…
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Identification of an immune biomarker for liver cancer
New immunotherapies may be developed for patients with HCC associated with steatotic liver disease, with TREM1 suggested as a target.
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A new genetic biomarker to predict immunotherapy success
Tumours with a greater IGR burden could respond better to immune checkpoint blockades, advancing precise treatments for patients.
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The implications of EN-1 overexpression in late-stage PDAC
Using tumour organoids, researchers identified that overexpression of Engrailed-1 blocked genes associated with natural cell death.
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Improved CAR T-cell immunotherapy for acute myeloid leukaemia
Researchers have created dual-targeted CARs, which performed better than single-targeted CARs in both in vivo and in vitro experiments.
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Lung adenocarcinoma: metabolic reprogramming of macrophages
Disrupting the mechanism that EGFR-driven lung adenocarcinoma uses to alter macrophages’ lipid metabolism could inspire new treatments.
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Investigating the intratumoural microbiome in young-onset CRC patients
New insights about young-onset CRC tumour-related bacteria could lead to new diagnostic markers and therapeutic targets.
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Integrin αV and β5 partner to drive cancer cell growth
A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.
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Reducing drug resistance in acute myeloid leukaemia patients
Researchers conducted a proteogenomic characterisation and found that drug exposure changes drug sensitivity.
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Organoid drug testing predicts bowel cancer treatment response
A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.
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How the DA subtype of Wilms tumour resists chemotherapy
Researchers suggest that DA histology slowly emerges by accumulating burdens of DNA damage and copy number aberrations.
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Application Note: Understanding The Multiplex Imaging Landscape
Learn about the different types of multiplexed imaging available, as well as their applications, benefits and disadvantages.
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Augmenting cancer immunogenicity through MHC class I
A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.
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Improving cancer treatment by exploiting mtDNA mutations
For the first time, mitochondrial DNA mutations could be used with immunotherapy to increase the chances of successful treatments.
