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Computational tool gets more out of multi-omics data
US researchers developed a next-generation computational tool called NetBID2 that can uncover difficult-to-identify proteins that drive biological processes contributing to cancer.
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Targets
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Challenges and promises of personalised precision medicine
Drug Target Review’s Taylor Mixides exclusively interviews Neil Thomas, Partner and Head of Healthcare and Life Sciences for EMEA at Infosys Consulting, on personalised precision medicine, its advances, challenges and the future.
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Special omega-3 fatty acid lipid plays critical role in the ageing brain
Scientists from Singapore have sought to understand the role of Mfsd2a in brain cells, in transporting lysophosphatidylcholine (LPC), a lipid that contains an omega-3 fatty acid
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Helper T cells may hold key to precision allergy treatment
US researchers have connected a rare T cell called Th9 with treating allergies, testing in mouse models with asthma.
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CRISPR and single-cell sequencing highlight genetic variants for traits and diseases
This article highlights a new approach to address human genetics, using STING-seq which provides roadmap to identify variants and genes, enabling deeper understanding of the noncoding genome and targets for therapies
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Reviving T cells to tackle immunotherapy-resistant cancers
US researchers utilise a new approach to immunotherapy, using exhausted T cells that could help overcome treatment resistance in cancers.
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Chances of eliminating HIV infection increased by dual gene-editing method
US researchers suggest that combing a dual gene-editing approach with antiretroviral drugs can eliminate HIV infections in animal models.
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Scientists uncover new insights into rare childhood liver cancer
Researchers from the Netherlands have utilised organoids and the CRISPR-Cas9 "molecular scissor" system to better understand the features and biology of fibrolamellar carcinoma (FLC), a rare type of liver cancer that affects adolescents and young adults.
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Blocking a microRNA may prevent age-related conditions
Conditions like chronic inflammation, muscle loss and bone loss have an elevated microRNA, US researchers attempted to block this in aged mice.
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Researchers establish the first human respiratory organoid culture system
A team from the University of Hong Kong has developed the first human respiratory organoid culture system, using it to unveil a novel mechanism for the high transmissibility of the SARS-CoV-2 Omicron variant.
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Study links nutrients, brain structure, cognition in healthy aging
US researchers found that nutrient intake, brain structure and cognitive function contribute to healthier brains in aging adults, by looking at correlating blood markers.
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Genetics behind facial and skull changes in Down Syndrome mouse model
Progress in identifying the gene responsible for facial and skull changes in mouse model of Down Syndrome, made by UK researchers.
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Light-activated graphene tattoo shows promise in treating heart rhythm disorders
This article outlines the development of the first cardiac implant made from graphene, which is thinner than a single strand of hair yet still functions like a classical pacemaker. It melds softly to the heart to simultaneously sense and treat irregular heartbeats, making it ideal for conforming to soft, dynamic…
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T cells show immunity to a variety of bacteria
Australian scientists explored a group of bacterial pathogens that share a protein sequence which is recognised by human T cells.
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Organ-on-a-chip device aids the study of thrombosis without animal models
Scientists from the University of Birmingham have developed an organ-on-a-chip-model to better understand the mechanisms of deep vein thrombosis.
