Unhealthy gut microbiomes in mice remodelled into more healthy ones
Scientists have shown that there are molecules to remodel the gut microbiome and turn an unhealthful gut into a more healthful one for the first time.
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Collaboration to discover MND treatments announced
MSD and the Francis Crick Institute will work together on a project to identify disease targets for motor neuron disease.
Immune cell function in cancer immunotherapy revealed
Researchers have discovered the roles that immune cells play in tumour growth and breast cancer immunotherapy which could aid in drug development.
Breast cancer progression may be halted with CRISPR gene editing
A tumour-targeted CRISPR gene editing system encapsulated in a nanogel could halt the growth of triple-negative breast cancer.
Researchers discover bronchospasms mechanisms using microdevice
A ‘bronchi-on-a-chip’ has been created by researchers to identify the processes of bronchospasms which could aid in respiratory disease therapies.
Study uncovers key processes behind MYC cancer gene
Researchers have discovered that MYC cancers use the cell’s machinery to make lipids and identified a lipid signature, which could be exploited in the development of new therapies.
Organ-on-an-electronic-chip could be used in drug development
Researchers have created a new organoid model that can be used to study systems such as the heart and the effects of drugs on these cells.
Study identifies novel measles drug target
Researchers have discovered the mechanism behind the viral genome for measles, which could serve as a druggable target.
Sickle cell drugs could be tested with help from new computer model
New computer model that simulates the way red blood cells become misshapen by sickle cell disease could identity promising drug candidates.
Succinate in cystic fibrosis lungs feeds deadly bacteria
Targeting a deadly bacteria's use of succinate in the lungs could control infection and improve the health of people with cystic fibrosis.
Gene linked to rare disorder also regulates key enzyme in Alzheimer’s
A gene associated with a rare balance disorder also regulates the behaviour of an enzyme that increases the risk for Alzheimer's disease.
Researchers image structure of cancer metastasis target
The structure of a key receptor involved in tumour metastasis has been imaged in a study, providing opportunities to develop cancer treatments.
Mechanism behind Piezo proteins discovered using imaging technique
A new study has used a combination of imaging methods to understand how the Piezo protein works, improving research into treatments for conditions such as high blood pressure.
Cyclisation reaction enables screening of macrocyclic compounds libraries
Libraries of more than 9,000 macrocyclic molecules below 1 KDa have been generated, small enough to cross cell membranes and reach targets.
Osteoporosis in mice reversed with new drug target
A pharmaceutical target has been identified by Duke University that, when activated, can reverse bone degradation caused by osteoporosis.
