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Root of childhood kidney cancer discovered
The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.
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Rachael Harper (Drug Target Review)
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New protein function could be key to treatment of drug addiction
Scientists have revealed new findings about the neural circuit involved in the reward stimulus, which plays a major role in drug dependence and psychological disorders.
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New treatment possible to tackle drug-resistant strains of TB
A new discovery could lead to the development of a drug for untreatable strains of TB, which can target uptake of the very amino acid that enables the bacteria to spread within the body.
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Cancer immunotherapies may be improved with early immune response
A new mechanism has been reported for detecting foreign material during early immune responses which may help detect elusive cancers.
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Medicine against bone disease found in Saussurea leaves
Isolated components found in the Saussurea controversa plant have antimicrobial and regenerative properties which could lead to a treatment for bone diseases.
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Study shows that CRISPR-Cas9 gene editing has a low risk of mistakes
A study has shown that unintended mutations from gene editing with CRISPR-Cas9 are rare in zebrafish, providing reassurance that this technology is a valid tool with great promise for the treatment of genetic disorders.
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Scientists discover how strep bacterium hides from the immune system
Produced by Group A Streptococcus, researchers have discovered the S protein, which binds to the red blood cell membrane to avoid being destroyed by immune cells and could be a target for anti-virulence drugs.
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Therapeutic target found for diseases caused by lipid accumulation in cells
Researchers have identified the protein Annexin A6 as a potential therapeutical target against diseases that are caused by the accumulation of cholesterol and other lipids in endosomes.
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Protein tag developed to aid in study of the immune system
A novel approach to better understand a basic defence mechanism of the immune system has been developed using the ISG15 protein which could lead to novel antimicrobial drugs.
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Direct link shown between inflammasome activation and Alzheimer’s
A new study has demonstrated that NLRP3 inflammasome directly drives tau pathology in neurodegenerative diseases and Alzheimer's disease.
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Novel pathway to target colorectal cancer identified
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
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Restarting metabolic process could make sarcoma susceptible to treatment
Researchers have found that soft tissue sarcoma cells stop a key metabolic process which allows them to spread and restarting that process could leave these cancers vulnerable treatments.
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Dengue vaccines may be improved by simulating amino acid starvation
Scientists have discovered that a plant-based compound called halofuginone activates a pathway that results in better antibodies and could improve the effectiveness of vaccines.
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Protein therapeutic development could be accelerated with new method
Scientists have developed a new method that accelerates the design and engineering of potential medicines and vaccines using glycosylation.
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Fungi library could aid in the search for medical drugs
A library of products derived from more than ten thousand fungi has been set up which could lead to the discovery of new drugs.