Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)

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Experimental mouse model reveals potential progeria treatment strategy

27 October 2021 | By Anna Begley (Drug Target Review)

Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.

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Blockade of MT4-MMP protease increases blood-patrolling monocyte activity

6 March 2018 | By Drug Target Review

Researchers in Spain have identified a function of the MT4-MMP protease (an enzyme that breaks down proteins) that could be targeted as a potential treatment for some infections, as well as tumour metastasis.

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CnAβ1 reduces cardiac hypertrophy and improves heart function

6 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified a variant of the enzyme calcineurin, called CnAβ1, whose action reduces cardiac hypertrophy and improves heart function...