A new CRISPR technology has been created to understand mutations based on cytosine to guanine base changes and minimise unintended "off-target" mutations.
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Massachusetts General Hospital (MGH)
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The 3D map, created using Knife-Edge Scanning Microscopy and analysed using laser capture microdissection, reveals new insights about the nervous control of the heart.
The Genome Aggregation Database (gnomAD) Consortium has released seven papers leveraging its database to study genetic variants and their potential for guiding discovery of safer drugs.
Research into the structure of the drug-integrin complex has enabled the creation of drugs which inhibit integrin as effectively as currently used compounds, without causing excessive bleeding.
Researchers have developed a new enzyme that prevents electron build-up in cells caused by aberrant mitochondria which could be a therapeutic technique for rare genetic conditions.
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
A study has demonstrated that inducing brain vessel pulsations helps to clear substances from the brains of mice, so could be used to stop amyloid-β build up in the development of Alzheimer’s.
It has been discovered that papillomaviruses induce immunity that protects patients, which could lead to a novel method for preventing skin cancer using a vaccine based on T cells.
A clinical study comparing liquid and tissue biopsies finds multiple resistance mechanisms in individual patients.
New lab on a chip technology has been developed to evaluate the effects of different drivers of NAFLD on liver cells.
A gene associated with a rare balance disorder also regulates the behaviour of an enzyme that increases the risk for Alzheimer's disease.
Using data collected from the UK, the data suggests that up to 25 million people in the US may be at more than triple the risk of coronary artery disease...
The structural protein is required for the chromosome to adopt a conformation that suppresses gene expression...
A new approach to analysing prostate gland tissue may help address a major challenge in treating prostate cancer...