All Stem Cells articles
-
NewsNUS researchers identify molecular switch driving TNBC treatment resistance
Researchers at the National University of Singapore have identified DP103 as a potential molecular master switch sustaining tumour growth, cancer stem cells and treatment resistance in triple-negative breast cancer, with findings suggesting it could serve as a predictive biomarker for the investigational oral therapy RX-5902.
-
NewsHuman heart organoids with functioning valves model cardiac valve disorders
Researchers have engineered human heart organoids complete with functioning valves, creating a physiologically relevant platform to study valve disorders including mitral valve prolapse and valve calcification, and potentially accelerating the search for new treatments.
-
NewsHow CAR T cells are being engineered to target tumour’s ‘soft spot’
A preclinical study published in Nature Biomedical Engineering describes a synthetic biology approach that converts the physical softness of cancer cells into a targetable signal for CAR-T immunotherapy, potentially addressing a key resistance mechanism in solid tumours.
-
ArticleReducing drug development failures with human-relevant models and AI
Professor Joseph C. Wu of Stanford University explains how stem cells, human-relevant models and AI are helping researchers predict which drug candidates are most likely to succeed before clinical trials.
-
NewsTargeting the roots of head and neck cancer: Why MDA-9 matters
A small molecule inhibitor developed at Virginia Commonwealth University has demonstrated the ability to eliminate cancer stem cells and reverse cisplatin resistance in preclinical models of head and neck squamous cell carcinoma, offering a potential new strategy to address one of oncology’s most persistent clinical challenges.
-
WebinarMeeting ethical & regulatory requirements when using human biological specimens
Whether you source, purchase or work with human biospecimens, understanding today’s ethical and regulatory expectations is essential. Join this webinar to explore informed consent, privacy and the principles that support responsible research.
-
NewsPancreas organoids reveal CFTR dysfunction as chronic pancreatitis drug target
Researchers at the Salk Institute have developed a patient-derived organoid platform that identifies distinct biological subtypes of chronic pancreatitis and highlights CFTR as a potential therapeutic target, raising prospects for more personalised treatments.
-
ArticleSynthetic iMSCs: reprogramming ovarian cancer from the inside out
Ovarian cancer has long proved difficult to treat. Could the answer lie within the disease itself? Discover how synthetic iMSCs could reprogramme the tumour microenvironment and restore anti-tumour immunity.
-
NewsStem cell organoids repair heart microvessels in coronary artery disease models
Stanford University researchers have demonstrated that stem cell-derived vascular organoids can regenerate damaged microvessels in the heart, improving cardiac function in a porcine model of ischaemic heart disease and addressing a significant unmet need in coronary artery disease treatment.
-
NewsSynthetic organiser cells enhance kidney organoid reproducibility and accuracy
Scientists at the University of Southern California have engineered synthetic organiser cells that produce localised Wnt signals to guide kidney organoid development, yielding more reproducible, physiologically accurate structures and revealing a previously unrecognised developmental axis in the human kidney.
-
Newsbit.bio launches iPSC-derived cell culture media kits to democratise human cell research
Cambridge-based cell programming company bit.bio has introduced two new media kits for its iPSC-derived ioGlutamatergic Neurons and ioMicroglia, reducing media preparation costs by around 18-fold and simplifying workflows to widen access to human-relevant research models.
-
NewsCerebral organoids identify Ebola virus persistence in neural tissue
Researchers have used human brain organoids to demonstrate that Ebola virus can replicate in neural tissue for up to 120 days, offering new insights into viral persistence mechanisms in immune-privileged sites and late-stage inflammatory complications in survivors.
-
ArticleCerebral organoids reveal how Ebola virus persists in neural tissue
How does Ebola virus survive long after recovery? A new study using human cerebral organoids explores viral persistence in neural tissue and the growing role of organoid models in drug discovery research.
-
NewsMineralised DNA hydrogel accelerates bone repair in preclinical studies
A mineralised DNA hydrogel has demonstrated accelerated bone repair and improved tissue mineralisation in preclinical studies, offering a potential new approach to treating difficult bone defects through combined immune regulation and sustained regeneration.
-
NewsNotch2 enables breast cancer dormancy in protective bone marrow niches
New research has demonstrated how breast cancer cells exploit protective bone marrow niches to remain dormant for years, identifying Notch2 signalling and stem cell-like markers as key regulators of cellular dormancy that could inform therapeutic strategies to prevent relapse.
-
NewsParse Biosciences and bit.bio map transcription factor-driven cell identity
Parse Biosciences and bit.bio have formed an alliance to map transcription factor-driven cell identity using single cell sequencing and causal transcriptomics.
-
NewsHow researchers are recreating the human heart in the lab
Many promising therapies fail because preclinical models do not fully capture the complexity of the human heart. A new review explores how 3D cardiac constructs could improve disease modelling, drug screening and safety assessment.
-
NewsCardiac organoids repair heart attack damage in preclinical study
Researchers have developed a scalable bioreactor-based system to produce cardiac organoids that successfully integrated into damaged heart tissue in porcine models of myocardial infarction, improving cardiac function and reducing scar formation without triggering arrhythmias.
-
NewsOrganoid study reveals valproate’s impact on developing brain
German researchers have used cerebral organoids to investigate how the epilepsy medication valproate interferes with early brain development, identifying significant disruption to the extracellular matrix and neuronal maturation that may explain increased neurodevelopmental risks in exposed foetuses.
-
News3D-printed system doubles growth speed of transplantable gut organoids
A novel 3D-printed confined culture system has enabled researchers to generate larger, more advanced human gastrointestinal organoids in half the time of traditional methods, producing transplantation-ready tissues with self-organised enteric neural networks within 14 days.