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Drug Discovery

 

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

method neuronal
method neuronal
article

Human neuronal cells: possibilities in drug safety testing

26 September 2023 | By

Human derived induced pluripotent stem cells (hiPSCs) have revolutionised research and are increasingly used for toxicology screening and disease modelling. Early detection of neurotoxicity induced by potential new therapies is a major challenge, and hiPSC-neuronal cells may provide a solution. These cells demonstrate considerable promise for uncovering drug-induced perturbations to…

Slices of mini–brain organoids with neural stem cells (red) and cortical neurons (green). (IMAGE)
Slices of mini–brain organoids with neural stem cells (red) and cortical neurons (green). (IMAGE)
article

How organoids can redefine pre-clinical research

22 September 2023 | By

Organoids, lab-grown 3D structures that mimic human organs, are redefining preclinical research through bypassing the ethical and practical limitations of animal models. Technological advancements in organoid research, including automation and improved analytical tools, promise to unlock new possibilities by streamlining the application of these 3D structures to enhance drug development…

In experiments in rats and mice, two Johns Hopkins scientists -- an engineer and an ophthalmologist -- report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye [credit: John Hopkins Medicine].
In experiments in rats and mice, two Johns Hopkins scientists -- an engineer and an ophthalmologist -- report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye [credit: John Hopkins Medicine].
article

Possible adulticidal drugs for Onchocerca volvulus

21 September 2023 | By

This article discusses the need for adulticidal drugs to treat Onchocerca volvulus infections, a parasite causing onchocerciasis (river blindness), as the current treatment with ivermectin and surgery presents challenges for affected communities. It highlights research findings on the potential of analgesic medicines to target adult worms and emphasises the importance…

Women scientists nurses and doctors fighting against coronavirus. Feminist steminist illustration. Female Doctors, nurses and scientists together.
Women scientists nurses and doctors fighting against coronavirus. Feminist steminist illustration. Female Doctors, nurses and scientists together.
article

Women in Stem with Theonie Anastassiadis

29 August 2023 | By

Join us for our monthly Women in STEM series where we showcase and celebrate the achievements of inspiring women in the field. This month we interview Theonie Anastassiadis, Cofounder & Chief Innovation Officer of Alltrna and Senior Principal of Flagship Pioneering. As a senior principal at Flagship Pioneering, Theonie conceives,…

webinar

Turning Plans into Reality: Real Examples of Custom Automation Projects

24 August 2023 | By Bio-Rad Laboratories Inc.

Watch our industry experts to learn about the tangible benefits and best practice of custom flow cytometry automation projects. You’ll discover how to reduce your challenges implementing tailored automation, controlling the quality of the data produced and improving the reliability of your data acquisition.