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Novel vaccine approach proves powerful against Zika virus
VSV acted as a vehicle to deliver the genes of some proteins from the Zika virus into mouse models, leading to immunity build up in the mice...
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Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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New drugs targeting gut microbes may reduce the risk of cardiovascular disease
The new class of drugs are mechanism-based inhibitors which potentially interrupt the gut microbial pathway that produces TMAO...
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New stem cell model to test treatments for neurodegenerative disorders
The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
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Potential peptide drug could treat liver cancer effectively
Researchers have discovered that FFW and Sorafenib used together could reduce the growth of Sorafenib resistant hepatocellular carcinoma tumours...
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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Monoclonal antibodies produced by new cell lines hope to improve drugs
Many biopharmaceutical companies look to produce biosimilars soon, since the patents on the original mAb expire over the next few years...
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Research into cellular signalling mechanisms may lead to new treatments
Wnt moves to specific areas of the cell membrane, interacting with a receptor known as Ror2, and inducing the formation of a cytoneme...
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Novel antibiotics can be found on common weeds
The team studied chemical compositions in detail and from one strain of bacteria several antibiotically active chemical substances were discovered...
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New ligand binding site identified through computer simulations
Many therapeutic compounds target GPCRs and so new ligand binding sites can help to design drugs more efficient at targeting GPCR...
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CMPK2 inhibitor could lesson symptoms of common illnesses
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
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New drug for ALS ready for clinical trials
Previous studies have suggested that a gene therapy drug may be used to treat ALS...
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BCX7353 shows hope for hereditary angioedema
A new drug has been developed to help prevent attacks of hereditary angioedema and at the same offer patients a convenient administration...
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Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...
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Adapting drug discovery to Artificial Intelligence
Drug discovery has always been challenging; today, more so than ever. While there has been success in addressing many diseases, others remain intractable...
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Improving the translation of disease biology though phenomics
How times change. Up to 15 years ago, you would be hard-pressed to find a drug discovery conference with a track dedicated to phenotypic approaches. The underpinning science was called high-content imaging or analysis, being mainly confined to academic drug discovery labs and a handful of pioneers in industry. but…
