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Drug Discovery

 

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

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The importance of adequately triaging hits from HTS campaigns

19 June 2015 | By , ,

High throughput screening (HTS) continues to be employed in drug discovery as the primary source of identifying chemical starting points for drug discovery and tool compounds for chemical biology, respectively. Although small molecule drug discovery efforts have focused largely upon enzyme, receptor and ion-channel targets, there has been an increase…

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Human pluripotent stem cell-derived cardiomyocytes in drug discovery and development

12 June 2015 | By , ,

Procedures for cardiac differentiation of human pluripotent stem cells (hPSCs) have greatly improved over the past few years. The facilitated derivation of hPSC-cardiomyocytes has enabled the thorough assessment of their physiology and manipulation of their properties. Moreover, patient-specific hPSCs generated through cellular reprogramming allow for cardiac disease modelling, discovery of…