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CIS43 antibody prevents malaria in mice
Scientists have discovered a human antibody that protected mice from infection with the deadliest malaria parasite, Plasmodium falciparum...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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PARK14 protein associated with inflammation in Parkinson’s
Study overturns previous ideas about enzyme linked to many illnesses
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Informatics In-Depth Focus 2018
In this In-Depth Focus: enabling research on understudied and unstudied targets, and using multi-omics data to detail drug responses in the human metabolic network.
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CRISPR-based system identifies drug targets in AML
Scientists have discovered a way to rein in an overactive protein that drives some aggressive leukaemias...
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Combination therapy suppresses HIV-like virus in primates
Broadly neutralising antibody treatment may target viral reservoir in monkeys...
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Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
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Blockade of MT4-MMP protease increases blood-patrolling monocyte activity
Researchers in Spain have identified a function of the MT4-MMP protease (an enzyme that breaks down proteins) that could be targeted as a potential treatment for some infections, as well as tumour metastasis.
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Scientists create complex transmembrane proteins from scratch
Advance paves the way for the design of transmembrane proteins with useful new functions...
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Change in neuron size could shed light on new treatments for ALS
Understanding how motor nerve cells respond to motor neurone disease could help researchers identify new treatment options...
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Scientists find that dectin-1 receptor protects against allergies
Contrary to previous notions that the receptor dectin-1 causes allergic reactions, new research from the John Hopkins Bloomberg School of Public Health has found that it actually prevents this response, indicating new targets for allergy and asthma drugs.
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Tempol provides a potential treatment for Chuvash polycythemia
A study in mice suggests that experimental drug may be effective against mountain sickness and other polycythemias...
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GAPSA reveals new HIV targets
Researchers have developed the first-ever high-throughput, genome-scale imaging-based approach to investigate protein stability...
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Antibodies provide potential targets for RSV vaccine development
Scientists have found and characterised the activity of four antibodies produced by the human immune system that targets an important protein found in the respiratory syncytial virus...
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The spreading mechanism of malaria parasites provides new drug target
A team of researchers in the UK have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, thus offering potential new treatment targets.
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Depleting BACE1 reverse the formation of amyloid plaques in Alzheimer’s disease
A team of researchers from the have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease...
