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A change in genetic code causes lung cancer to develop
Using lung basal cell organoids, researchers identify a gene that directs the development of lung cancer and offers a better understanding of its disease treatment.
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Genetic Analysis
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Study identifies gene and proteins that could treat dry eye disease
Researchers found that proteins made by stem cells that regenerate the cornea could be new targets for treating dry eye disease.
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New method precisely locates gene activity and proteins across tissues
The scientists argue the technique enables the creation of complex, data-rich “maps” of organs, including diseased organs and tumours, which could be widely useful in pre-clinical research.
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Spatial lung cell atlas offers insights into disease and immune function
Researchers have genetically profiled nearly 200,000 cells from lungs, mapping their precise locations in tissue to discover an unexpected new immune niche in our airways.
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Scientists investigate the multi-omic landscape of NAFLD-to-NASH progression
Researchers have presented comprehensive multi-omic profiles to identify genes, non-coding RNAs, proteins, and plasma metabolites involved in NAFLD-to-NASH progression.
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Pattern of gene activity for ADHD is unlocked
US researchers identified that those with ADHD have differences in gene activity in the brain.
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Researchers develop and test risk score for pSSNS
Scientists have generated polygenic risk scores for developing paediatric steroid sensitive nephrotic syndrome (pSSNS), a kidney disease in children.
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New control system created for synthetic genes
MIT researchers have developed a technique that could help the production of monoclonal antibodies and other useful proteins.
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Study offers new insights into genetic mutations in ASD
The study’s findings have important implications for better understanding the neurological basis for ASD and developing effective therapies for patients.
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How neurons stimulate the brain’s microglia
A new MIT study highlights ailing neurons may activate an inflammatory response from the brain’s microglia immune cells.
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Stem cell study reveals how neurons from PTSD patients react to stress
The findings provide insight into how genetics can make someone more susceptible to developing PTSD following trauma exposure.
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Exploring gene interactions in influenza to improve accuracy of flu vaccines
Researchers from the University of Illinois at Urbana-Champaign found the evolutionary potential of influenza A virus haemagglutinin is extremely restricted by epistatic interactions with neuraminidase.
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New gene target for small-cell lung cancer discovered
Deleting the gene POU2AF2 kills cancer cells in deadly subtype of small-cell lung cancer.
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Neonatal ketone body determines premature ovarian ageing
The researchers found that ketone body deficiency in neonatal mice resulted in smaller ovarian follicle reservoir because of the increased apoptosis of primordial follicles.
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Genomic studies could impact pneumococcal disease vaccine design
A recent genomic surveillance study has demonstrated the value of genomics to inform vaccine design and highlight the challenge posted by shapeshifting bacteria.
