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26 April 2018 | By Charles River Laboratories
This webinar highlights cell based assays for Parkinson’s disease that include endpoints such as a-synuclein aggregation and mitophagy readouts.
Scientists have developed a breakthrough CRISPR gene-editing tool, that could allow researchers to quickly and precisely engineer multiple changes to the genetic code...
This recent webinar focused on the role of IntelliCyt’s iQue Screener PLUS platform as a high throughput suspension cell screening platform to facilitate simultaneous assessment of multiple parameters, while using minimal sample volumes.
Declining R&D productivity is a key challenge in the pharmaceutical industry. To increase the success rate of candidate drugs entering the clinical phase, companies must address the early stages of drug discovery.
Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...
The Compendium provides scientists an online resource to help design efficient in vitro and in vivo oncology research studies.
1 February 2018 | By PerkinElmer
This webinar discussed a screening assay that recapitulates the activation of ER stress sensor IRE1 and an assay to quantify cell migration phenotypes, as applied to cardiovascular target validation and drug discovery.
Researchers have identified the sirtuin enzyme as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting a potential therapeutic target for type 2 diabetes...
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
Charles River Laboratories International, Inc. announced the expansion of its CRISPR/Cas9 service offering with the addition of a license from ERS Genomics Limited.
A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses.
Partnership with InSphero provides additional 3D solutions...
Researchers have performed meta-analysis of neurological and neurodegenerative diseases and created an atlas of how cell characteristics are linked to their genotype...
