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A new vision: restoring eyesight using a novel gene therapy technique
Scientists created a technique to give photoreceptors infrared-light sensitivity, allowing the animal models to see infrared heat signatures.
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In Vivo
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Researchers suggest animal experiments may be too standardised to be reproducible
Experts suggest that increasing biological and conditional variations in their experiments could not only make them more reproducible but also reduce the total number of animals required.
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Protective immunity to SARS-CoV-2 shown in non-human primates
Macaques were protected against SARS-CoV-2 infection both after an initial infection and vaccination with a prototype vaccine, researchers suggest humans could respond similarly.
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Developing respiratory therapeutics for prophylaxis and treatment
Drug Target Review explores antiviral Fc-conjugates and how they could be used as a COVID-19 prophylactic and therapeutic with Dr Jeff Stein, Cidara’s President and CEO.
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In vitro platforms for de-risking nephrotoxicity during drug development
If not correctly assessed, drug candidates with undesirable safety issues may progress through clinical development, resulting in costly failures later in the development process. Given that many drugs fail in clinical trials due to nephrotoxicity, this article describes the importance of understanding kidney transporter function in drug development, how current…
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New optical technique affords unique insight into blood cell development
Scientists in Hong Kong have developed a novel optical technique that facilitates accurate tracking of hemogenic endothelium cells in zebrafish embryos, providing new insights into the mechanisms of blood formation and potential new understanding of diseases such as leukaemia.
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Innate protein restricts HIV replication by targeting lipid rafts
According to a new study, apolipoprotein A-I binding protein restricts HIV-1 replication by targeting lipid rafts and reducing virus-cell fusion.
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Autophagy: the key to effective MERS-coronavirus treatment?
A promising route for tackling the often-fatal MERS-coronavirus (MERS-CoV) has been identified by researchers in Germany.
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Brain cancer model developed to study glioblastoma
Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.
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Diabetes-related proteins examined for the first time at high resolution
A key receptor has been examined for the first time at high resolution which could lead to better treatments for conditions such as type 2 diabetes.
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Getting precise: how humanised models aid in biologics drug discovery
Humanised immune system (HIS) models have enabled numerous in vivo evaluations of immuno-modulating biologic drugs and ongoing improvements continue to extend their utility. Paul Volden explores the application of HIS models in precision and personalised medicine with a focus on biologics, including how HIS models are used, why they are…
whitepaper
eBook: Simple as a Selfie: One-Button Scientific Imaging
Proper signal visualization, detection, and quantification are paramount to the acquisition of accurate and reproducible data...
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Application note: In Vivo Imaging with GFP
Challenge: Non-invasive imaging of a patient-derived orthotropic mouse model of pancreatic cancer expressing GFP. The solution? In vivo imaging.
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eBook – Getting the Inside Story: In Vivo Imaging
In vivo imaging has been an indispensable and powerful tool in biomedical research, enabling a number of significant breakthrough discoveries.
