news
Study identifies two enzymes which protect tumour cells
Researchers have found an enzyme and its counterpart which inhibit T-cells from attacking tumour cells.
List view / Grid view
Mass Spectrometry
article
Compound and fragment screening by native mass spectrometry
Native mass spectrometry has the potential to be a fast, simple, highly sensitive and automatable technique for compound screening in drug design and discovery. In this article, Rod Chalk and Nicola Burgess-Brown discuss the key attributes of native mass spectrometry and reasons why it is not yet widely employed.
article
Bringing native analysis into the fast-moving world of biologics
For the past thirty years, native mass spectrometry has grown in both scope and reach in labs across the globe to encompass larger and more challenging molecular complexes. However, up until now, the throughput of these techniques has been slow and manual. Christopher Nortcliffe discusses ways that native analysis is…
article
Screening In-Depth Focus 2019
This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.
article
Drug Target Review – Issue 2 2019
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
news
Proteomics research advanced by use of AI
Researchers succeed in using machine learning to make the mass analysis of proteins faster and almost error-free.
news
New mass spectrometry system for finding potential drugs
New method for computational mass spectrometry will speed up the discovery of natural products that could be used in medicines...
article
Leveraging the power of HTS in the new and rapidly evolving collaborative drug discovery landscape
Over the last five years drug discovery has undergone a rapid evolution from a closed and proprietary endeavour to an open and collaborative process. Large and small pharma now openly collaborate with each other and the wider academic world to leverage their collective depth of knowledge to increase the chances…
whitepaper
Application note: Enabling single-software multiple attribute methodology (MAM) for the assessment of biopharmaceutical product quality attributes
Development and production of biopharmaceuticals is complex. Even minor impurities, or changes in attributes such as glycosylation or charge heterogeneity, can have a profound impact on the safety and efficacy of the final product. Traditionally, multiple analytical techniques have been required to assess the full range of biopharmaceutical product attributes.…
news
Algorithm to more effectively identify antibiotic compounds
An international team of scientists has developed a candidate identification technique in the form of an algorithm that reduces the chances of rediscovering known compounds.
news
CT45 biomarker found in ovarian cancer can predict response to therapy
New approach could prolong survival and trigger an immune...
article
Mass spectrometry and drug development – how the two come together
Since the development of the so-called soft ionisation techniques: electrospray ionisation and matrix-assisted laser desorption and ionisation in the 1980s and early 1990s and the development of high-resolution mass spectrometers, mass spectrometry (MS) has come to the fore in studying complex biological systems...
news
D-PDMP reverses hair loss and skin damage linked to fatty diet
In a series of experiments, researchers have used an experimental compound to successfully reverse hair loss, hair whitening and skin inflammation...
news
Breath tests could detect pancreatic cancer
Breath tests analysing organic compounds in exhaled breath could be used as a new diagnostic tool for pancreatic cancer...
