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Richard Goodwin joins DTR Advisory Board
Dr Goodwin is the latest top-level scientist to join DTR's advisory board
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Mass Spectrometry
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Mass spectrometry imaging in drug discovery
Mass spectrometry imaging allows direct measurement of the molecular composition of a sample. It can be used to image the spatial distribution of exogenous drugs and endogenous metabolites simultaneously over the surface of tissue sections or small biopsy, allowing new insights into both compound efficacy and safety during drug discovery.
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Imaging In-Depth Focus 2017
This In-Depth Focus explores current uses and future development in mass spectrometry imaging for bringing new drugs to market...
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Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...
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UC biologist looks at butterflies to help solve human infertility
UC biologist helps decode the structural complexities of male butterfly ejaculate and co-evolving female reproductive tract. Findings from these biochemical relationships may help unlock certain mysteries of human infertility
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Using native mass spectrometry to inform drug discovery
Mass spectrometry (MS) performed under native-like conditions (nMS) is a promising approach for studying protein-drug interactions, and has already informed treatments of some of the most intractable diseases including cancer, diabetes and Alzheimer’s.
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Drug Target Review – Issue #2 2017
Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...
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Metabolic markers accurately diagnose typhoid fever
Researchers have identified a metabolite 'signature' that can accurately distinguish typhoid from other fever-inducing tropical diseases using patient blood samples.
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New method for early screening of colorectal cancer
A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan.
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Creating the ‘google earth’ of tumours
We caught up with Dr Josephine Bunch to find out how NPL are using the Cancer Research Grand Challenge funding & novel imaging techniques to map cancer tumours...
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EU funds research on biofuels and infectious diseases
Biochemist and physician Professor Ivan Dikic and microbiologist Professor Volker Müller are very honoured that their pioneering research projects have been selected for this substantial financial support.
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Breath test could help detect stomach and oesophageal cancers
A test that measures the levels of five chemicals in the breath has shown promising results for the detection of oesophageal and stomach cancers, in a large patient trial.
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The next revolution in stratified medicine: molecular phenotyping with metabolomics
The study of biochemistry provides molecular insights into how the human population ages, how diseases commence and progress, how molecular changes relate to disease remission and relapse, and how humans respond to treatments...
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Advanced techniques and applications of LC-MS in small molecule drug discovery
A key process in drug discovery is the ability to identify new drug candidates by screening chemical libraries of small molecules, natural products or extracts against a biological target and selecting lead compounds with desirable therapeutic effects. Medicinal chemistry has the challenging role of not only ensuring that the chemical…
