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Mass Spectrometry

 

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Advanced techniques and applications of LC-MS in small molecule drug discovery

16 June 2016 | By , , ,

A key process in drug discovery is the ability to identify new drug candidates by screening chemical libraries of small molecules, natural products or extracts against a biological target and selecting lead compounds with desirable therapeutic effects. Medicinal chemistry has the challenging role of not only ensuring that the chemical…

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Analysing recombinant proteins by mass spectrometry

5 December 2015 | By , , ,

The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…