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COVID-19 vaccines should not be affected by SARS-CoV-2 mutations, researchers say

12 October 2020 | By Victoria Rees (Drug Target Review)

A common SARS-CoV-2 mutation known as D614G should not impact on the efficacy of COVID-19 vaccines, a study has shown.

SARS-CoV-2 particles in grey and red - SARS-CoV-2 is the virus that causes COVID-19

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Researchers suggest blocking factor D protein could combat SARS-CoV-2

9 October 2020 | By Victoria Rees (Drug Target Review)

A team has said that inhibiting the factor D protein could prevent SARS-CoV-2 from turning the immune system against healthy cells.

EEG waves indicating an epileptic seizure overlaid with a brain

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Single-nucleus transcriptomics reveals novel epilepsy targets

8 October 2020 | By Hannah Balfour (Drug Target Review)

Study reveals which neurons are most affected by epilepsy, presenting novel targets for seizure drug discovery and development.

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SARS-CoV-2 mechanism of infection revealed using cryo-electron microscopy

8 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the surface of SARS-CoV-2 can take on at least 10 different structural states when in contact with ACE2.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

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Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

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Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

stand of DNA behing a side on view of the human head with the brain highlighted in red

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Epigenetic marks could be the target of future Alzheimer’s therapies

2 October 2020 | By Hannah Balfour (Drug Target Review)

New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.

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Antibodies from recovered COVID-19 patients inhibit SARS-CoV-2 infection in cells

28 September 2020 | By Victoria Rees (Drug Target Review)

Pre-clinical studies in cells and hamsters have shown that potent antibodies from COVID-19 patients can prevent infection from SARS-CoV-2.

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Interactive 3D model of SARS-CoV-2 surface released

25 September 2020 | By Victoria Rees (Drug Target Review)

A new interactive map of the surface of SARS-CoV-2, featuring the Spike, Envelope and Membrane proteins, has been released for researchers to use.

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

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Experimental antiviral AR-12 could be a promising COVID-19 treatment

23 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.

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Researchers discover druggable pocket on SARS-CoV-2 Spike protein

22 September 2020 | By Victoria Rees (Drug Target Review)

A pocket in the SARS-CoV-2 Spike protein has been discovered by researchers, who say it could be a drug target for COVID-19.

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Novel pseudo-virion probes to study SARS-CoV-2 viral entry

18 September 2020 | By Hannah Balfour (Drug Target Review)

The non-infectious quantum dot probes are designed to enable researchers to safely study interactions between the SARS-CoV-2 Spike (S) protein and human cells.

Lungs in red on a bright blue background

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Mystery glycoprotein could prevent respiratory distress

18 September 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, the DMBT1S8 molecule can halt inflammation in the respiratory tract through its interaction with the Siglec-8 receptor on immune cells.

brain with a cutaway of viral particles in orange surrounding a blue neuron - idea of viral encepalopathy

news

A novel drug target for viral encephalitis therapies

17 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers showed CXCL1 signalling to neutrophils drove brain inflammation in herpes simplex virus (HSV) encephalitis and blocking the protein resulted in less severe disease.

news

Drug target to combat three coronavirus diseases identified by researchers

16 September 2020 | By Victoria Rees (Drug Target Review)

Researchers studying the PLpro binding site of three coronaviruses, including SARS-CoV-2, say the BL2 loop could be targeted by antiviral drugs.

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