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Vaccine

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Genetic analysis of SARS-CoV-2 reveals one vaccine could combat all infections

2 September 2020 | By Victoria Rees (Drug Target Review)

A genetic analysis of SARS-CoV-2 sequences reveal the virus has mutated minimally since December 2019, suggesting only one vaccine is needed to combat COVID-19.

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UK government to invest £8.4 million into COVID-19 immunology research

1 September 2020 | By Victoria Rees (Drug Target Review)

The UK government will invest £8.4 million in COVID-19 research projects to reveal more information that can be used to develop therapies and vaccines against the disease.

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Researchers emphasise importance of antigen valency for vaccine efficacy

28 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have shown that factoring in valency to vaccine design can improve the number of antibody binding sites on an antigen.

close up photo of a syringe drawing liquid from a medicine vial

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Novel vaccine protects mice against Staphylococcus aureus infection, say researchers

21 August 2020 | By Hannah Balfour (Drug Target Review)

The novel vaccine 4X-SA-GP harnesses the anti-fungal immune response to provide immunity against Staphylococcus aureus (S. aureus) infection.

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COVID-19 vaccine elicits high levels of neutralising antibodies in mice

17 August 2020 | By Victoria Rees (Drug Target Review)

A potential COVID-19 vaccine, made from a modified vesicular stomatitis virus with the SARS-CoV-2 Spike protein, was shown to protect mice against the virus.

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Potential COVID-19 treatment and vaccine combination shows success in cells

12 August 2020 | By Victoria Rees (Drug Target Review)

A possible treatment and vaccine combination for COVID-19 has shown positive results in pre-clinical studies using human cells.

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Atomic-scale details of SARS-CoV-2 Spike protein from vaccine obtained

11 August 2020 | By Victoria Rees (Drug Target Review)

The SARS-CoV-2 Spike protein from a COVID-19 vaccine candidate has been characterised by researchers, supporting the neutralising antibody response it elicits.

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Tuberculosis vaccine shown to protect older mice with type 2 diabetes

11 August 2020 | By Victoria Rees (Drug Target Review)

A study in older mice with type 2 diabetes revealed a tuberculosis vaccine elicited a strong immune response, making it a promising candidate for the condition.

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Five biomarkers revealed as indicators of COVID-19 patient survival

10 August 2020 | By Victoria Rees (Drug Target Review)

Five immune response biomarkers have been identified by researchers who say they can be used to classify which COVID-19 patients will survive the disease.

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Largest sequencing study of SARS-CoV-2 presents six separate strains

6 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have sequenced SARS-CoV-2, revealing at least six strains with little variability, useful information for vaccine developers.

article

Coronavirus update: COVID-19 vaccine pre-clinical developments

5 August 2020 | By Victoria Rees (Drug Target Review)

Drug Target Review rounds up some of the latest news in COVID-19 vaccine candidate R&D.

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Team redesigns COVID-19 Spike protein for more stable vaccines

24 July 2020 | By Victoria Rees (Drug Target Review)

Researchers have modified the COVID-19 Spike protein for use in vaccines, which produces up to 10 times more protein than that of an earlier synthetic versions.

white mouse next to vial of COVID-19 vaccine

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Nanoparticle COVID-19 vaccine elicits immune response in pre-clinical studies

21 July 2020 | By Hannah Balfour (Drug Target Review)

The vaccine candidate repRNA-CoV2S elicited both antibody and T cell responses after just two injections in mice and macaques.

antibodies attacking black covid-19 particles

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Most antibodies targeting SARS-CoV-2 use specific immunoglobulin subtype

14 July 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal IgHV3-53 is the most common immunoglobulin mutation used to target the receptor binding domain on the SARS-CoV-2 spike protein.

article

Prophylactics for COVID-19 – known and unknown

9 July 2020 | By Alan Olan

This article outlines the ideal scientific research that should be conducted to design a prophylactic to combat COVID-19.

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Vaccine