3-D bioprinted tissues as disease-in-a-dish models for drug screening
More than 90% of drugs that enter clinical evaluation fail to reach approval because of lack of efficacy or unexpected toxicity. This failure rate is in large part due to the use of overly simplistic in-vitro cell-based assays and animal models with limited predictive value…
As knowledge of cellular processes in humans and research technologies have improved, it has become more apparent that the complexity of cellular pathways, disease-relevant cellular backgrounds, cell-cell interactions, and cellular-microenvironment interactions in tissues are critical for the understanding of drug efficacy and toxicity in humans, and are considerations that need to be integrated into future drug discovery in vitro cell-based assays.
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National Center for Advancing Translational Sciences' (NCATS)