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Informatics In-Depth Focus 2019
In this In-Depth Focus: AI-driven automated chemistry as a tool…
In this In-Depth Focus: AI-driven automated chemistry as a tool to accelerate drug discovery, and a look at network-driven drug discovery
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Anton Simeonov
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Informatics In-Depth Focus 2018
In this In-Depth Focus: enabling research on understudied and unstudied…
In this In-Depth Focus: enabling research on understudied and unstudied targets, and using multi-omics data to detail drug responses in the human metabolic network.
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Machine learning approaches as tools to accelerate drug discovery
Computational methods based on machine learning approaches are being introduced…
Computational methods based on machine learning approaches are being introduced increasingly widely to screen the large number of molecules that have never participated in the drug discovery process, but which might have significant drug development potential. This article considers the latest advances in machine learning as applied to drug discovery...
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Screening In-Depth Focus 2017
In this In-Depth Focus on Screening, we look at clinically-oriented…
In this In-Depth Focus on Screening, we look at clinically-oriented phenotypic screening and explore how 3-D bioprinted tissues can be used as disease-in-a-dish models for drug screening.
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3-D bioprinted tissues as disease-in-a-dish models for drug screening
More than 90% of drugs that enter clinical evaluation fail…
More than 90% of drugs that enter clinical evaluation fail to reach approval because of lack of efficacy or unexpected toxicity. This failure rate is in large part due to the use of overly simplistic in-vitro cell-based assays and animal models with limited predictive value...
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Drug Target Review – Issue #2 2017
Included in this issue: Technology convergence improves testing; Screening; Stem…
Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...
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Assays In-Depth Focus 2017
HTS can be carried out in a number of formats,…
HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole animal screening assay formats. Horst Flotow, from Hit Discovery Constance, discusses the benefits and practicalities of, and recent progress in, whole animal screening. Madhu Lal-Nag, National Center for Advancing Translational Sciences, and Anton…
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Stem Cells In-Depth Focus 2016
Featured in this Stem Cells In-depth Focus: Translating stem cell…
Featured in this Stem Cells In-depth Focus: Translating stem cell biology into drug discovery; Mechanism-informed phenotypic screening – the missing link for cancer drug discovery; Analysis of human stem cell interactions at the single-cell resolution...
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Enzymes: Ubiquitin-specific proteases as druggable targets
In much the same way that kinases and phosphatases attach…
In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
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Anton Simeonov
Acting Branch Chief and Group Leader, National Institutes of Health
6 February 2014 | By
Acting Branch Chief and Group Leader, National Institutes of Health