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Anton Simeonov

 

Informatics In-Depth Focus 2018

In this In-Depth Focus: enabling research on understudied and unstudied…

15 March 2018 | By

In this In-Depth Focus: enabling research on understudied and unstudied targets, and using multi-omics data to detail drug responses in the human metabolic network.

Machine learning approaches as tools to accelerate drug discovery

Computational methods based on machine learning approaches are being introduced…

12 December 2017 | By ,

Computational methods based on machine learning approaches are being introduced increasingly widely to screen the large number of molecules that have never participated in the drug discovery process, but which might have significant drug development potential. This article considers the latest advances in machine learning as applied to drug discovery...

Screening In-Depth Focus 2017

In this In-Depth Focus on Screening, we look at clinically-oriented…

11 December 2017 | By

In this In-Depth Focus on Screening, we look at clinically-oriented phenotypic screening and explore how 3-D bioprinted tissues can be used as disease-in-a-dish models for drug screening.

Drug Target Review – Issue #2 2017

Included in this issue: Technology convergence improves testing; Screening; Stem…

2 June 2017 | By

Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...

Assays In-Depth Focus 2017

HTS can be carried out in a number of formats,…

15 March 2017 | By , , ,

HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole animal screening assay formats. Horst Flotow, from Hit Discovery Constance, discusses the benefits and practicalities of, and recent progress in, whole animal screening. Madhu Lal-Nag, National Center for Advancing Translational Sciences, and Anton…

Stem Cells In-Depth Focus 2016

Featured in this Stem Cells In-depth Focus: Translating stem cell…

16 June 2016 | By , , , ,

Featured in this Stem Cells In-depth Focus: Translating stem cell biology into drug discovery; Mechanism-informed phenotypic screening – the missing link for cancer drug discovery; Analysis of human stem cell interactions at the single-cell resolution...

Enzymes: Ubiquitin-specific proteases as druggable targets

In much the same way that kinases and phosphatases attach…

21 September 2015 | By ,

In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…

Anton Simeonov

Acting Branch Chief and Group Leader, National Institutes of Health

6 February 2014 | By

Acting Branch Chief and Group Leader, National Institutes of Health