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Expert view: Targeting the cGAS-STING pathway with a new Transcreener HTS assay

Posted: 24 March 2020 | | No comments yet

DNA in the cytoplasm is an indicator of microbial infection, serving as a danger signal and resulting in induction of an innate immune response via the cyclic GAMP synthase (cGAS)/STING (Stimulator of INterferon-sensitive Genes) pathway.

However, aberrant activation of cGAS by self-DNA triggers a type I interferon (IFN) response that contributes to a growing list of autoimmune and inflammatory conditions, including lupus, age-related macular degeneration, inflammatory bowel disease and nonalcoholic steatohepatitis. Knockout studies in animal models have clearly indicated that inhibiting cGAS is a promising approach for therapeutic intervention.











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