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A Guide to Measuring Drug-Target Residence Times
This guide provides technical background on concepts and techniques for use of Transcreener biochemical assays to measure drug-target residence times.
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BellBrook Labs
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Whitepaper: Targeting kinases in the innate immune response
The guide provides examples of how Transcreener allowed rapid assay development to enable screening for kinases in innate immune pathways.
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A Guide to DNA Damage Response and Innate Immunity
In this guide, we provide an overview of the DDR and innate immune pathway and describe Transcreener Assays and Assay Systems for key targets.
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Unique self-activating proteins for drug discovery
Naegleria fowleri infections are rare but almost invariably fatal, with pathologic sequelae spawning its common label as ‘the brain-eating amoeba’. Researchers identified two unique proteins within N. fowleri – self-activating guanine nucleotide-hydrolysing proteins (G proteins) – that present novel targets for drug discovery. This article summarises their work to date,…
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Drug Target Review Assays ebook 2023
Download your FREE ebook on assays, featuring articles from experts who write about developments in screening and the importance of performing comprehensive multiplex spatial and temporal profiling of drugs in pre-clinical research.
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Guide: Navigating hit prioritisation using biochemical assays
So you have performed your screen. What’s next? This guide is focused on how biochemical assays are used for characterising and prioritising compounds.
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Expert view: Targeting the cGAS-STING pathway with a new Transcreener HTS assay
DNA in the cytoplasm is an indicator of microbial infection, serving as a danger signal and resulting in induction of an innate immune response via the cyclic GAMP synthase (cGAS)/STING (Stimulator of INterferon-sensitive Genes) pathway.