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High-throughput calcium flux assays: luminescent versus fluorescent readout

20 September 2016 | By , , ,

In vitro high-throughput cellular target-based assays are commonly used for hit identification targeting G-protein coupled receptors (GPCR). Agonist and antagonist identification of GPCRs often relies on the screening of large collections of chemicals using miniaturised in vitro cell-based functional assays. In the panel of assays, calcium mobilisation measured by aequorin…

Fibromyalgia pathogenesis provides drug target clues

20 September 2016 | By

Fibromyalgia (FM) has been described as a condition of heightened generalised sensitisation to sensory input presenting as a complex of symptoms dominated by chronic widespread pain characterised by hyperalgesia and allodynia. A range of co-morbidities of variable intensity, such as fatigue, sleep disturbance, cognitive impairment, anxiety and depression, are often…

Could Pokémon Go help curb the diabetes pandemic?

15 August 2016 | By Niamh Louise Marriott, Digital Content Producer

Drug Target Review caught up with Dr Emily Burns, Research Communications Manager Diabetes UK to find out how this smartphone craze could impact the rising levels of Diabetes…

Moderna discuss mRNA therapeutics in cystic fibrosis

22 July 2016 | By Victoria White, Digital Content Producer

Drug Target Review recently caught up with Lorence Kim, Chief Financial Officer of Moderna, to find out more about the company‘s collaboration with Vertex and using mRNA therapeutics to treat patients with cystic fibrosis...

How NIH’s $30 million research fund will help find HIV cure

20 July 2016 | By Niamh Louise Marriott, Digital Content Producer

The NIH recently awarded $30 million to advance science towards a cure for HIV. Drug Target Review caught up with the Wistar Institute‘s Dr. Luis Montaner, co-leader of the BEAT-HIV project...

Lyme disease: mystery, misery and hope

15 July 2016 | By Victoria White, Digital Content Producer

Drug Target Review recently caught up with Veronica Hughes, CEO of the Caudwell Lyme Disease charity, to find out more about the disease...

EU Referendum: Tell us what you think…

20 June 2016 | By Caroline Richards, Editor, Drug Target Review

As Britons go to polling stations to vote in the EU Referendum, we can't help but wonder how you feel...