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The frightening emergence of antibiotic-resistant bacteria

17 February 2016 | By ,

Bacterial resistance to antibiotics is on the rise and a return to the ‘pre-antibiotic’ era has become a frightening possibility. Various factors are responsible for this situation: the overuse of antibiotics in human medicine and animal husbandry, insufficient public funding for research into fundamental bacteriology including resistance mechanisms, and a…

The relevance of homogeneous radiometric assays in modern drug discovery

14 February 2016 | By ,

In the past two decades, several alternative, non-radiometric assay formats have been developed for the high-throughput screening (HTS) of target classes such as protein kinases, which were previously screened using radiometric assays. Radiometric screening (and the expertise to perform such HTS) has thus declined in recent years...

Wanted: Zika virus researchers

10 February 2016 | By Victoria White, Digital Content Producer, Drug Target Review

The MRC has launched a £1m rapid response funding initiative to better understand the nature of the risk posed by the Zika virus. Find out about this initiative and NIH's call for research here...

canSAR: a portal to Big Data for drug discovery

9 February 2016 | By Dr Bissan Al-Lazikani and Elizabeth Coker, The Institute of Cancer Research, London

Dr Bissan Al-Lazikani and Elizabeth Coker discuss canSAR: the first public domain example of Big Data for drug discovery...

Zika Virus: a public emergency of international concern

4 February 2016 | By Victoria White, Digital Content Producer, Drug Target Review

The Zika virus has taken hold in South America. Its possible link to microcephaly in newborn babies and neurological conditions has led the World Health Organization to declare a Public Health Emergency of International Concern. Here we discuss the virus, countermeasures and the race for a vaccine...

Drug Target Review’s top 10 stories from 2015

28 January 2016 | By Victoria White, Digital Content Producer, Drug Target Review

2015 was an exciting year for the drug discovery industry. Here we look at a selection of stories that particularly stood out for us…

Analysing recombinant proteins by mass spectrometry

5 December 2015 | By , , ,

The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…

Mass spectrometry and systems biology approaches in drug target discovery

5 December 2015 | By

Cells, organs and organisms are complex biological systems consisting of inter-related components that co-operatively work to maintain function and respond to change. Malfunction of any component can lead to pathologies and disease, leading to system-wide changes and subsequent adaptation. Hence, the ability to study and predict system behaviour will considerably…